{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:28:30Z","timestamp":1792812510744,"version":"4.5.0"},"reference-count":26,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Fifty-two percent of 1,288 poultry isolates of campylobacters were ampicillin resistant, and resistance was more common among\n                    <jats:italic>Campylobacter coli<\/jats:italic>\n                    isolates (67.4%) than among\n                    <jats:italic>Campylobacter jejuni<\/jats:italic>\n                    isolates (47.5%). Production of \u03b2-lactamase was typically associated with resistance to ampicillin, amoxicillin (amoxicilline), penicillin, and ticarcillin. Regardless of \u03b2-lactamase production, all isolates were resistant to piperacillin (MICs \u2265 256 \u03bcg\/ml), and most were resistant to carbenicillin, cloxacillin, and cephalosporins. Of all ampicillin-resistant campylobacters tested, 91% (347\/380) carried the\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>OXA-61<\/jats:sub>\n                    gene, and 77% (136\/175) of those tested with nitrocefin produced a \u03b2-lactamase, presumably OXA-61. The isoelectric point (pI) of OXA-61 was 8.7, and the molecular mass was 31.0 kDa. Insertional inactivation of\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>OXA-61<\/jats:sub>\n                    in\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>jejuni<\/jats:italic>\n                    NCTC 11168 and two ampicillin-resistant isolates resulted in increased susceptibility to ampicillin, co-amoxiclav (amoxicillin and clavulanic acid), penicillin, carbenicillin, oxacillin, and piperacillin, but the effects on MICs of cephalosporins and imipenem were negligible. Some\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>jejuni<\/jats:italic>\n                    isolates that lacked\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>OXA-61<\/jats:sub>\n                    produced a \u03b2-lactamase, CjBla2, with a pI of 9.2 and molecular mass of 32.4 kDa. Mass spectrometry confirmed that the most prevalent \u03b2-lactamase was the product of\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>OXA-61<\/jats:sub>\n                    , but CjBla2 was not identified. OXA-61 is prevalent among\n                    <jats:italic>Campylobacter<\/jats:italic>\n                    spp. of veterinary origin and is similar to the \u03b2-lactamase previously reported in human isolates. Production of OXA-61 was associated with resistance to penams but not cephalosporins. Co-amoxiclav remained active against all isolates tested.\n                  <\/jats:p>","DOI":"10.1128\/aac.01655-08","type":"journal-article","created":{"date-parts":[[2009,6,8]],"date-time":"2009-06-08T21:49:59Z","timestamp":1244497799000},"page":"3357-3364","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":92,"title":["\u03b2-Lactamase-Mediated \u03b2-Lactam Resistance in\n                    <i>Campylobacter<\/i>\n                    Species: Prevalence of Cj0299 (\n                    <i>bla<\/i>\n                    <sub>OXA-61<\/sub>\n                    ) and Evidence for a Novel \u03b2-Lactamase in\n                    <i>C<\/i>\n                    .\n                    <i>jejuni<\/i>"],"prefix":"10.1128","volume":"53","author":[{"given":"Deborah J.","family":"Griggs","sequence":"first","affiliation":[{"name":"Antimicrobial Agents Research Group, Division of Immunity and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanne","family":"Peake","sequence":"additional","affiliation":[{"name":"Antimicrobial Agents Research Group, Division of Immunity and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Antimicrobial Agents Research Group, Division of Immunity and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba","family":"Ghori","sequence":"additional","affiliation":[{"name":"Antimicrobial Agents Research Group, Division of Immunity and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mott","sequence":"additional","affiliation":[{"name":"Antimicrobial Agents Research Group, Division of Immunity and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J. V.","family":"Piddock","sequence":"additional","affiliation":[{"name":"Antimicrobial Agents Research Group, Division of Immunity and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.6.2515-2518.2005"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1574-695X.2006.00197.x","volume":"49","year":"2007","unstructured":"Alfredson, D. A., and V. Korolik. 2007. Identification of putative zinc hydrolase genes of the metallo-\u03b2-lactamase superfamily from Campylobacter jejuni. FEMS Immunol. Med. Microbiol.49:159-164.","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"e_1_3_2_4_2","first-page":"1948","year":"1995","unstructured":"Blaser, M. J. 1995. Campylobacter and related species, p. 1948-1956. In G. L. Mandell, J. E. Bennett, and R. 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