{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T09:57:23Z","timestamp":1782554243142,"version":"3.54.5"},"reference-count":12,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Targeted airway delivery of antifungals as prophylaxis against invasive aspergillosis may lead to high lung drug concentrations while avoiding toxicities associated with systemically administered agents. We evaluated the effectiveness of aerosolizing the intravenous formulation of voriconazole as prophylaxis against invasive pulmonary aspergillosis caused by\n            <jats:italic>Aspergillus fumigatus<\/jats:italic>\n            in an established murine model. Inhaled voriconazole significantly improved survival and limited the extent of invasive disease, as assessed by histopathology, compared to control and amphotericin B treatments.\n          <\/jats:p>","DOI":"10.1128\/aac.01657-08","type":"journal-article","created":{"date-parts":[[2009,3,17]],"date-time":"2009-03-17T00:54:09Z","timestamp":1237251249000},"page":"2613-2615","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["Inhaled Voriconazole for Prevention of Invasive Pulmonary Aspergillosis"],"prefix":"10.1128","volume":"53","author":[{"given":"Justin A.","family":"Tolman","sequence":"first","affiliation":[{"name":"The University of Texas at Austin College of Pharmacy, Austin, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan P.","family":"Wiederhold","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin College of Pharmacy, Austin, Texas"},{"name":"The University of Texas Health Science Center at San Antonio, Pharmacotherapy Education and Research Center, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason T.","family":"McConville","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin College of Pharmacy, Austin, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura K.","family":"Najvar","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, San Antonio, Texas"},{"name":"South Texas Veterans Health Care System, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosie","family":"Bocanegra","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, San Antonio, Texas"},{"name":"South Texas Veterans Health Care System, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay I.","family":"Peters","sequence":"additional","affiliation":[{"name":"South Texas Veterans Health Care System, San Antonio, Texas"},{"name":"The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Pulmonary Diseases\/Critical Care Medicine, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline J.","family":"Coalson","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at San Antonio, Graduate School of Biomedical Sciences, Department of Pathology, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Graybill","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"Patterson","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, San Antonio, Texas"},{"name":"South Texas Veterans Health Care System, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Robert O.","family":"Williams","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin College of Pharmacy, Austin, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1399-3062.2006.00125.x","volume":"8","year":"2006","unstructured":"Alexander, B. D., E. S. Dodds Ashley, R. M. Addison, J. A. Alspaugh, N. J. Chao, and J. R. Perfect. 2006. Non-comparative evaluation of the safety of aerosolized amphotericin B lipid complex in patients undergoing allogeneic hematopoietic stem cell transplantation. Transpl. Infect. Dis.8:13-20.","journal-title":"Transpl. Infect. Dis."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.12.3474-3481.2001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/513943"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2003.09.028"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/318483"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1086\/586739","volume":"46","year":"2008","unstructured":"Rijnders, B. J., J. J. Cornelissen, L. Slobbe, M. J. Becker, J. K. Doorduijn, W. C. Hop, E. J. Ruijgrok, B. Lowenberg, A. Vulto, P. J. Lugtenburg, and S. de Marie. 2008. Aerosolized liposomal amphotericin B for the prevention of invasive pulmonary aspergillosis during prolonged neutropenia: a randomized, placebo-controlled trial. Clin. Infect. Dis.46:1401-1408.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00787-06"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.5.1908-1911.2004"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1086\/591531","volume":"47","year":"2008","unstructured":"Slobbe, L., S. Polinder, J. K. Doorduijn, P. J. Lugtenburg, A. el Barzouhi, E. W. Steyerberg, and B. J. Rijnders. 2008. Outcome and medical costs of patients with invasive aspergillosis and acute myelogenous leukemia-myelodysplastic syndrome treated with intensive chemotherapy: an observational study. Clin. Infect. Dis.47:1507-1512.","journal-title":"Clin. Infect. 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