{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:52:14Z","timestamp":1791035534821,"version":"4.1.0"},"reference-count":40,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The sulfonamides were the first drugs with antituberculous effects. Their use was abandoned and basically forgotten with the advent of streptomycin and isoniazid combination treatment. There is a widespread belief, apparently based on testing a single isolate on questionable media, that<jats:italic>Mycobacterium tuberculosis<\/jats:italic>is resistant to trimethoprim-sulfamethoxazole (TMP-SMX). We saw a complex immunocompromised patient with tuberculosis who was initially treated with TMP-SMX without antituberculous drugs and defervesced on this treatment. An isolate of<jats:italic>M. tuberculosis<\/jats:italic>from this patient was found to be sensitive to TMP-SMX. We examined how frequently<jats:italic>M. tuberculosis<\/jats:italic>is sensitive to TMP-SMX. Isolates were tested for susceptibility to TMP-SMX on supplemented Middlebrook 7H10 plates. We found that 43 of 44 (98%) isolates of<jats:italic>M. tuberculosis<\/jats:italic>were susceptible to the combination of \u22641 \u03bcg\/ml of TMP and 19 \u03bcg\/ml of SMX (\u22641\/19 \u03bcg\/ml). Thus, the vast majority of our<jats:italic>M. tuberculosis<\/jats:italic>isolates were susceptible to TMP-SMX at an MIC similar to that for<jats:italic>Mycobacterium kansasii<\/jats:italic>,<jats:italic>Mycobacterium marinum<\/jats:italic>, and sensitive rapidly growing mycobacteria, organisms successfully treated with TMP-SMX as part of the treatment regimen. It is possible that TMP-SMX may be useful in treating patients with multiple-drug-resistant and extended drug-resistant tuberculosis. We feel that a clinical trial looking at the effectiveness of TMP-SMX as an antituberculous drug is worthwhile.<\/jats:p>","DOI":"10.1128\/aac.01658-08","type":"journal-article","created":{"date-parts":[[2009,6,30]],"date-time":"2009-06-30T00:59:24Z","timestamp":1246323564000},"page":"4789-4793","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":90,"title":["Tuberculosis and Trimethoprim-Sulfamethoxazole"],"prefix":"10.1128","volume":"53","author":[{"given":"Pierre","family":"Forgacs","sequence":"first","affiliation":[{"name":"Departments of Infectious Diseases and Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy L.","family":"Wengenack","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Clinical Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L.","family":"Silverman","sequence":"additional","affiliation":[{"name":"Anatomic Pathology, Lahey Clinic Medical Center, Burlington, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn D.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07399-1"},{"key":"e_1_3_2_3_2","first-page":"8","volume":"1","year":"1971","unstructured":"Anonymous. 1971. 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