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M\u00f8ller Fonden | Fonden til L\u00e6gevidenskabens Fremme","award":["L-2023-00097"],"award-info":[{"award-number":["L-2023-00097"]}]},{"name":"Eva Merete Falck Crones Fond","award":["10-100071"],"award-info":[{"award-number":["10-100071"]}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2025,6,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              In a\n              <jats:italic toggle=\"yes\">Mycobacterium heraklionense<\/jats:italic>\n              tenosynovitis case, we observed that azithromycin-loaded calcium sulfate beads placed in the surgical wound had minimal systemic absorption and achieved over 100-fold higher target tissue concentrations than a systemic azithromycin-based treatment regimen alone. However, continued excessive wound drainage necessitated surgical removal of the beads. While systemic antibiotics and surgery remain central to nontuberculous mycobacterial treatment, the role of local antibiotic administration in reducing the bacterial burden warrants further investigation.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/aac.01670-24","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T13:00:29Z","timestamp":1742216429000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["<i>Mycobacterium heraklionense<\/i>\n            hand tenosynovitis\u2014a case description of a three-year treatment course and perioperative measurement of azithromycin target tissue concentrations"],"prefix":"10.1128","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1688-954X","authenticated-orcid":true,"given":"Mads Kristian","family":"Duborg Mikkelsen","sequence":"first","affiliation":[{"name":"Aarhus Denmark Microdialysis Research 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