{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T10:49:15Z","timestamp":1774435755162,"version":"3.50.1"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100012399","name":"Biomedical Advanced Research and Development Authority","doi-asserted-by":"publisher","award":["HHSO100201900007C, 75A50122C00080"],"award-info":[{"award-number":["HHSO100201900007C, 75A50122C00080"]}],"id":[{"id":"10.13039\/100012399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2025,5,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              We determined the frequency of resistance to cefepime-taniborbactam in NDM-1-producing\n              <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n              at &lt;10\n              <jats:sup>\u221210<\/jats:sup>\n              . Isolated mutants that were less susceptible to cefepime-taniborbactam had an increased copy number of the\n              <jats:italic toggle=\"yes\">bla<\/jats:italic>\n              <jats:sub>NDM-1<\/jats:sub>\n              gene or disruption of major porins OmpK36 and OmpK35. Antibacterial susceptibility testing using\n              <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n              isogenic strains indicated that while cefepime penetrates into the periplasm mainly through the major porins, taniborbactam does not have a strong dependence on OmpK35 or OmpK36 for periplasmic accumulation.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/aac.01672-24","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T22:57:11Z","timestamp":1743634631000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Impact of porin deletions on cefepime-taniborbactam activity against\n            <i>Klebsiella pneumoniae<\/i>"],"prefix":"10.1128","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6994-4286","authenticated-orcid":true,"given":"Tsuyoshi","family":"Uehara","sequence":"first","affiliation":[{"name":"Venatorx Pharmaceuticals Inc.","place":["Malvern, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassandra L.","family":"Chatwin","sequence":"additional","affiliation":[{"name":"Venatorx Pharmaceuticals Inc.","place":["Malvern, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brittany","family":"Miller","sequence":"additional","affiliation":[{"name":"Venatorx Pharmaceuticals Inc.","place":["Malvern, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell","family":"Edwards","sequence":"additional","affiliation":[{"name":"Venatorx Pharmaceuticals Inc.","place":["Malvern, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Venatorx Pharmaceuticals Inc.","place":["Malvern, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna","family":"Colombo","sequence":"additional","affiliation":[{"name":"Venatorx Pharmaceuticals Inc.","place":["Malvern, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Uehara","sequence":"additional","affiliation":[{"name":"Venatorx Pharmaceuticals Inc.","place":["Malvern, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9287-2997","authenticated-orcid":true,"given":"Denis M.","family":"Daigle","sequence":"additional","affiliation":[{"name":"Venatorx Pharmaceuticals Inc.","place":["Malvern, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b01518"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01963-19"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-024-02082-9"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac492.022"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00236-24"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.11.2312"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00069-5"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkad210"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01332-23"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00579-23"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01570-23"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkae329"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2012.03796.x"},{"key":"e_1_3_4_15_2","volume-title":"Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; Approved standards","author":"CLSI","year":"2018","unstructured":"CLSI. 2018. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; Approved standards. 11th ed. doi:. Clinical Laboratory Standards Institute.","edition":"11"},{"key":"e_1_3_4_16_2","volume-title":"Performance standards for antimicrobial susceptibility testing","author":"CLSI","year":"2021","unstructured":"CLSI. 2021. Performance standards for antimicrobial susceptibility testing. 31st ed. doi:. Clinical Laboratory Standards Institute.","edition":"31"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062774"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.10.3332-3335.2003"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx285"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00590-16"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-023-04697-4"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00751-24"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01281-22"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01410-12"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00085-10"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01443-17"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.01672-24","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.01672-24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T13:01:57Z","timestamp":1746622917000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.01672-24"}},"subtitle":[],"editor":[{"given":"Ryan K.","family":"Shields","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,5,7]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5,7]]}},"alternative-id":["10.1128\/aac.01672-24"],"URL":"https:\/\/doi.org\/10.1128\/aac.01672-24","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,7]]},"assertion":[{"value":"2024-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01672-24"}}