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An adenylate kinase-based assay was optimized for\n            <jats:named-content content-type=\"genus-species\">S. mutans<\/jats:named-content>\n            to detect cell lysis when exposed to the Selleck library (Selleck Chemical, Houston, TX) of 853 FDA-approved drugs in, to our knowledge, the first high-throughput drug screen in\n            <jats:named-content content-type=\"genus-species\">S. mutans<\/jats:named-content>\n            . We found 126 drugs with activity against\n            <jats:named-content content-type=\"genus-species\">S. mutans<\/jats:named-content>\n            planktonic cultures, and they were classified into six categories: antibacterials (61), antineoplastics (23), ion channel effectors (9), other antimicrobials (7), antifungals (6), and other (20). These drugs were also tested for activity against\n            <jats:named-content content-type=\"genus-species\">S. mutans<\/jats:named-content>\n            biofilm cultures, and 24 compounds were found to inhibit biofilm formation, 6 killed preexisting biofilms, 84 exhibited biofilm inhibition and killing activity, and 12 had no activity against biofilms. The activities of 9 selected compounds that exhibited antimicrobial activity were further characterized for their activity against\n            <jats:named-content content-type=\"genus-species\">S. mutans<\/jats:named-content>\n            planktonic and biofilm cultures. Together, our results suggest that\n            <jats:named-content content-type=\"genus-species\">S. mutans<\/jats:named-content>\n            exhibits a susceptibility profile to a diverse array of established and novel antibacterials.\n          <\/jats:p>","DOI":"10.1128\/aac.01674-17","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T00:40:25Z","timestamp":1508805625000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["A Drug Repositioning Approach Reveals that Streptococcus mutans Is Susceptible to a Diverse Range of Established Antimicrobials and Nonantibiotics"],"prefix":"10.1128","volume":"62","author":[{"given":"S.","family":"Saputo","sequence":"first","affiliation":[{"name":"Center for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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