{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T21:25:32Z","timestamp":1773696332402,"version":"3.50.1"},"reference-count":50,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We tested 29 isolates of\n            <jats:named-content content-type=\"genus-species\">Pythium insidiosum<\/jats:named-content>\n            and one isolate of\n            <jats:named-content content-type=\"genus-species\">Pythium aphanidermatum<\/jats:named-content>\n            to investigate their susceptibility to miltefosine and antibacterial drugs from the macrolide, oxazolidinone, and pleuromutilin classes. We found that miltefosine, azithromycin, clarithromycin, josamycin, linezolid, sutezolid, retapamulin, tiamulin, and valnemulin had inhibitory and cidal activity against the pathogens at concentrations ranging from 0.25 to 64 \u03bcg\/ml. Our results suggest that these antimicrobials are promising candidates for future studies on pythiosis in animals and humans.\n          <\/jats:p>","DOI":"10.1128\/aac.01678-17","type":"journal-article","created":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T11:54:42Z","timestamp":1515498882000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["<i>In Vitro<\/i>\n            Activities of Miltefosine and Antibacterial Agents from the Macrolide, Oxazolidinone, and Pleuromutilin Classes against Pythium insidiosum and Pythium aphanidermatum"],"prefix":"10.1128","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0408-5294","authenticated-orcid":false,"given":"Erico S.","family":"Loreto","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Centro de Ci\u00eancias da Sa\u00fade, Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil"},{"name":"Sobresp Faculdade de Ci\u00eancias da Sa\u00fade, Santa Maria, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5036-3270","authenticated-orcid":false,"given":"Juliana S. M.","family":"Tondolo","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Farmacologia, Centro de Ci\u00eancias da Sa\u00fade, Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele C.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Sobresp Faculdade de Ci\u00eancias da Sa\u00fade, Santa Maria, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janio M.","family":"Santurio","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Farmacologia, Centro de Ci\u00eancias da Sa\u00fade, Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5740-387X","authenticated-orcid":false,"given":"Sydney H.","family":"Alves","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Centro de Ci\u00eancias da Sa\u00fade, Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12281-013-0144-z"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2007.10.013"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/506353"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1534734615599652"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02352-16"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00154-16"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02680-13"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02349-14"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00073-12"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01586-10"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01480-15"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001162"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp160248"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001419"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01209-11"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00410-15"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-010-9781-4"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177868"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00437925"},{"key":"e_1_3_1_21_2","first-page":"658","article-title":"A method for obtaining zoospores of Pythium aphanidermatum and their use in determining cucurbit seedling resistance to damping-off","volume":"63","author":"Rahimian M","year":"1979","unstructured":"Rahimian M, Banihashemi Z. 1979. 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