{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:18:04Z","timestamp":1791033484286,"version":"4.1.0"},"reference-count":47,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Acinetobacter baumannii<\/jats:italic>\n            strains resistant to all \u03b2-lactams, aminoglycosides, and fluoroquinolones have emerged in many medical centers. Potential mechanisms contributing to antimicrobial resistance were investigated in 40 clinical isolates endemic to New York City. The isolates were examined for the presence of various \u03b2-lactamases, aminoglycoside-modifying enzymes, and mutations in\n            <jats:italic>gyrA<\/jats:italic>\n            and\n            <jats:italic>parC<\/jats:italic>\n            . Expression of the genes encoding the \u03b2-lactamase AmpC, the efflux systems AdeABC and AbeM, and the OmpA-like porin was also examined by real-time reverse transcription-PCR. No VIM, IMP, KPC, OXA-23-type, OXA-24-type, or OXA-58 \u03b2-lactamases were detected, although several isolates had acquired\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>SHV-5<\/jats:sub>\n            . Most cephalosporin-resistant isolates had increased levels of expression of\n            <jats:italic>ampC<\/jats:italic>\n            and\/or had acquired\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>SHV-5<\/jats:sub>\n            ; however, isolates without these features still had reduced susceptibility to cefepime that was mediated by the AdeABC efflux system. Although most isolates with IS\n            <jats:italic>Aba1<\/jats:italic>\n            upstream of the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>OXA-51<\/jats:sub>\n            -like carbapenemase gene were resistant to meropenem, several remained susceptible to imipenem. The presence of aminoglycoside-modifying enzymes and gyrase mutations accounted for aminoglycoside and fluoroquinolone resistance, respectively. The increased expression of\n            <jats:italic>adeABC<\/jats:italic>\n            was not an important contributor to aminoglycoside or fluoroquinolone resistance but did correlate with reduced susceptibility to tigecycline. The expression of\n            <jats:italic>abeM<\/jats:italic>\n            and\n            <jats:italic>ompA<\/jats:italic>\n            and phenotypic changes in OmpA did not correlate with antimicrobial resistance.\n            <jats:italic>A. baumannii<\/jats:italic>\n            has become a well-equipped nosocomial pathogen; defining the relative contribution of these and other mechanisms of antimicrobial resistance will require further investigation.\n          <\/jats:p>","DOI":"10.1128\/aac.01684-07","type":"journal-article","created":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:34:56Z","timestamp":1214872496000},"page":"2999-3005","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":110,"title":["Correlation of Antimicrobial Resistance with \u03b2-Lactamases, the OmpA-Like Porin, and Efflux Pumps in Clinical Isolates of\n            <i>Acinetobacter baumannii<\/i>\n            Endemic to New York City"],"prefix":"10.1128","volume":"52","author":[{"given":"Simona","family":"Bratu","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, SUNY Downstate Medical Center, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Landman","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, SUNY Downstate Medical Center, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don Antonio","family":"Martin","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, SUNY Downstate Medical Center, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu","family":"Georgescu","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, SUNY Downstate Medical Center, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Quale","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, SUNY Downstate Medical Center, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.9.3299-3305.2000"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.2.428-432.2000"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/421495"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.47019-0"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2004.01016.x"},{"key":"e_1_3_2_7_2","unstructured":"Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically approved standard 7th ed. 2006 vol. 26"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf092"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.12.5172-5175.2005"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.2.491-496.2004"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr050143q"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg097"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.2.358-363.1996"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.30.10.2680-2685.1992"},{"key":"e_1_3_2_15_2","first-page":"434","volume":"47","year":"2003","unstructured":"Gribun, A., Y. 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