{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T04:30:22Z","timestamp":1781929822704,"version":"3.54.5"},"reference-count":39,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Paratek Pharmaceuticals"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              Nocardiosis typically requires a prolonged treatment duration of \u22656 months and initial combination therapy with 2\u20133 antibiotics. First-line regimens for nocardiosis are associated with considerable toxicity; therefore, alternative therapies are needed. Omadacycline is an aminomethylcycline with broad antimicrobial activity whose\n              <jats:italic>in vitro<\/jats:italic>\n              activity against\n              <jats:italic>Nocardia<\/jats:italic>\n              species has not been formally assessed. The\n              <jats:italic>in vitro<\/jats:italic>\n              potency of omadacycline was evaluated against 300\n              <jats:italic>Nocardia<\/jats:italic>\n              clinical isolates by broth microdilution. The most common\n              <jats:italic>Nocardia<\/jats:italic>\n              species tested were\n              <jats:italic>N. cyriacigeorgica<\/jats:italic>\n              (21%),\n              <jats:italic>N. nova<\/jats:italic>\n              (20%), and\n              <jats:italic>N. farcinica<\/jats:italic>\n              (12%). The most common specimens were respiratory (178 isolates, 59%) and wound (57 isolates, 19%). Omadacycline minimum inhibitory concentrations (MICs) across all\n              <jats:italic>Nocardia<\/jats:italic>\n              species ranged from 0.06 \u00b5g\/mL to 8 \u00b5g\/mL, with an MIC\n              <jats:sub>50<\/jats:sub>\n              of 2 \u00b5g\/mL and MIC\n              <jats:sub>90<\/jats:sub>\n              of 4 \u00b5g\/mL. The lowest MICs were found among\n              <jats:italic>N. paucivorans<\/jats:italic>\n              (MIC\n              <jats:sub>50<\/jats:sub>\n              = 0.25 \u00b5g\/mL, MIC\n              <jats:sub>90<\/jats:sub>\n              = 0.25 \u00b5g\/mL),\n              <jats:italic>N. asiatica<\/jats:italic>\n              (MIC\n              <jats:sub>50<\/jats:sub>\n              = 0.25 \u00b5g\/mL, MIC\n              <jats:sub>90<\/jats:sub>\n              = 1 \u00b5g\/mL),\n              <jats:italic>N. abscessus<\/jats:italic>\n              complex (MIC\n              <jats:sub>50<\/jats:sub>\n              = 0.5 \u00b5g\/mL, MIC\n              <jats:sub>90<\/jats:sub>\n              = 1 \u00b5g\/mL),\n              <jats:italic>N. beijingensis<\/jats:italic>\n              (MIC\n              <jats:sub>50<\/jats:sub>\n              = 0.5 \u00b5g\/mL, MIC\n              <jats:sub>90<\/jats:sub>\n              = 2 \u00b5g\/mL), and\n              <jats:italic>N. otitidiscaviarum<\/jats:italic>\n              (MIC\n              <jats:sub>50<\/jats:sub>\n              = 1 \u00b5g\/mL, MIC\n              <jats:sub>90<\/jats:sub>\n              = 2 \u00b5g\/mL). The highest MICs were found among\n              <jats:italic>N. farcinica<\/jats:italic>\n              (MIC\n              <jats:sub>50<\/jats:sub>\n              = 4 \u00b5g\/mL, MIC\n              <jats:sub>90<\/jats:sub>\n              = 8 \u00b5g\/mL).\n              <jats:italic>In vitro<\/jats:italic>\n              potency differed by species among\n              <jats:italic>Nocardia<\/jats:italic>\n              clinical isolates. Further studies are warranted to evaluate the potential clinical utility of omadacycline for nocardiosis.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/aac.01686-23","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T13:09:58Z","timestamp":1711544998000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["<i>In vitro<\/i>\n            activity of omadacycline against clinical isolates of\n            <i>Nocardia<\/i>"],"prefix":"10.1128","volume":"68","author":[{"given":"Jonathan","family":"Pham","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3235-6285","authenticated-orcid":true,"given":"Russell J.","family":"Benefield","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Utah Health, Salt Lake City, Utah, USA"},{"name":"Department of Pharmacotherapy, University of Utah College of Pharmacy, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natali","family":"Baker","sequence":"additional","affiliation":[{"name":"Associated Regional and University Pathologists (ARUP) Laboratories, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane","family":"Lindblom","sequence":"additional","affiliation":[{"name":"Associated Regional and University Pathologists (ARUP) Laboratories, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Canfield","sequence":"additional","affiliation":[{"name":"Associated Regional and University Pathologists (ARUP) Laboratories, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5486-5710","authenticated-orcid":true,"given":"Carlos A.","family":"Gomez","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA"},{"name":"Associated Regional and University Pathologists (ARUP) Laboratories, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.19.2.259-282.2006"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13509"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00027-21"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01419-17"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000404"},{"key":"e_1_3_2_7_2","volume-title":"Manual of clinical Microbiology","author":"Brown-Elliott BA","year":"2023","unstructured":"Brown-ElliottBA, Zelazny AM, Conville PS. 2023. 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