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Mortality rates among patients receiving antifungal drug treatment range from 30% to 90%. Therefore, there is an urgent need to improve the efficacy of antifungal drug therapies against infections by these high-priority fungal diseases.\n                      <jats:italic toggle=\"yes\">Aspergillus fumigatus<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Cryptococcus neoformans<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">Rhizopus delemar<\/jats:italic>\n                      are the most common causative pathogens. We have previously developed DectiSomes, which are liposomes loaded with antifungal drugs and coated with the carbohydrate recognition domains of mouse Dectin-1 and\/or Dectin-2. We demonstrated that the murine DectiSomes efficiently bound and killed these pathogens growing\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      and\/or in mouse disease models. With the plan to move DectiSomes into the clinic with the human Dectin orthologs, we were concerned that the significant sequence divergence between mouse and human Dectin-1 and Dectin-2 carbohydrate recognition domains could have altered pathogen specificity. Herein, we compared the functionality of the human and mouse Dectin-1 and Dectin-2 orthologs in targeting DectiSomes to these pathogens. Binding and growth inhibition data on\n                      <jats:italic toggle=\"yes\">A. fumigatus<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">C. neoformans<\/jats:italic>\n                      supported their functional similarity, while results with\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">R. delemar<\/jats:italic>\n                      indicated some functional divergence. Despite these differences, our results demonstrate that both human and mouse DectiSomes are effective at binding and killing all four diverse fungal pathogens.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.01689-25","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:01:01Z","timestamp":1774875661000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Human Dectin-1- and Dectin-2-targeted DectiSomes are effective against diverse pathogenic fungi"],"prefix":"10.1128","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4658-0245","authenticated-orcid":true,"given":"Suresh","family":"Ambati","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00te3t702","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Genetics, University of Georgia","place":["Athens, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3390-8387","authenticated-orcid":true,"given":"Xiaorong","family":"Lin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00te3t702","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology, University of Georgia","place":["Athens, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1735-8266","authenticated-orcid":true,"given":"Zachary A.","family":"Lewis","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00te3t702","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology, University of Georgia","place":["Athens, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7589-3265","authenticated-orcid":true,"given":"Jesse A.","family":"Peter","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00te3t702","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Genetics, University of Georgia","place":["Athens, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3928-8403","authenticated-orcid":true,"given":"Richard B.","family":"Meagher","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00te3t702","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Genetics, University of Georgia","place":["Athens, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofab593"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00692-8"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2023.101393"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13338"},{"key":"e_1_3_4_6_2","unstructured":"WHO. 2022. 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