{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:11:13Z","timestamp":1791655873858,"version":"4.3.4"},"reference-count":15,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"HHS | National Institutes of Health","award":["5U19AI166798-02"],"award-info":[{"award-number":["5U19AI166798-02"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2025,3,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Infusion reactions (tachycardia, hypertension, fever, etc.) associated with liposomal amphotericin B are common. Animal models have found complement activation responsible, yet the pathophysiology has not been evaluated in human patients. We performed a prospective observational study and found complement activation-related pseudoallergy (CARPA) responsible in those with infusion reactions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.01692-24","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T09:00:43Z","timestamp":1738227643000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["Liposomal amphotericin B and complement activation-related pseudoallergy (CARPA)"],"prefix":"10.1128","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8518-5750","authenticated-orcid":true,"suffix":"III","given":"George R.","family":"Thompson","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Infectious Diseases, University of California-Davis Medical Center","place":["Sacramento, USA"]},{"name":"Department of Medical Microbiology and Immunology, University of California-Davis","place":["Davis, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gelina M.","family":"Sani","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of California Davis Medical Center","place":["Sacramento, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica A.","family":"Donnelley","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of California Davis Medical Center","place":["Sacramento, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaimie K.","family":"Figueroa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Infectious Diseases, University of California-Davis Medical Center","place":["Sacramento, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Ciuffetelli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Infectious Diseases, University of California-Davis Medical Center","place":["Sacramento, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Trigg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Infectious Diseases, University of California-Davis Medical Center","place":["Sacramento, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Arredondo","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of California-Davis","place":["Davis, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Koff","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Infectious Diseases, University of California-Davis Medical Center","place":["Sacramento, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Nearing","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of California-Davis","place":["Davis, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikaika C.","family":"Loque","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of California-Davis","place":["Davis, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek J.","family":"Bays","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Infectious Diseases, University of California-Davis Medical Center","place":["Sacramento, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satya","family":"Dandekar","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of California-Davis","place":["Davis, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis290"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/22.Supplement_2.S133"},{"key":"e_1_3_3_4_2","unstructured":"Liposomal amphotericin B [package insert]. 2012. 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