{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:02:50Z","timestamp":1792605770115,"version":"4.5.0"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Linezolid is an antibiotic with time-dependent activity, and both the percentage of time that plasma concentrations exceed the MIC and the area under the concentration-time curve over 24 h in the steady state divided by the MIC (AUC\n            <jats:sub>24<\/jats:sub>\n            \/MIC ratio) are associated with clinical response. The aim of this study was to analyze the linezolid trough plasma concentration (\n            <jats:italic>C<\/jats:italic>\n            <jats:sub>min<\/jats:sub>\n            ) and to determine factors associated with a\n            <jats:italic>C<\/jats:italic>\n            <jats:sub>min<\/jats:sub>\n            &lt; 2 mg\/liter and other clinically relevant thresholds. Characteristics of 78 patients receiving 600 mg\/12 h of linezolid with a\n            <jats:italic>C<\/jats:italic>\n            <jats:sub>min<\/jats:sub>\n            determination at the steady state and within the first 10 days of treatment were retrospectively reviewed. Concentrations were measured using high-pressure liquid chromatography. Univariate and multivariate analysis were performed to identify risk factors of low\n            <jats:italic>C<\/jats:italic>\n            <jats:sub>min<\/jats:sub>\n            . A total of 29.5% of patients had a\n            <jats:italic>C<\/jats:italic>\n            <jats:sub>min<\/jats:sub>\n            &lt; 2 mg\/liter. The percentage was significantly higher in patients with an estimated glomerular filtration (eGF) &gt; 80 ml\/min, in intensive care unit (ICU) patients, and in patients with an infection due to\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Staphylococcus aureus<\/jats:named-content>\n            . The independent predictors of\n            <jats:italic>C<\/jats:italic>\n            <jats:sub>min<\/jats:sub>\n            &lt; 2 mg\/liter were an eGF &gt; 80 ml\/min (odds ratio [OR], 10; 95% confidence interval [CI], 2.732 to 37.037;\n            <jats:italic>P<\/jats:italic>\n            = 0.001) and infection due to\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. aureus<\/jats:named-content>\n            (OR, 5.906; 95% CI, 1.651 to 21.126;\n            <jats:italic>P<\/jats:italic>\n            = 0.006). A linezolid\n            <jats:italic>C<\/jats:italic>\n            <jats:sub>min<\/jats:sub>\n            of &lt;2 mg\/liter was found in 29.5% of cases, and the risk was significantly higher among those with an eGF &gt; 80 ml\/min and in infections due to\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. aureus<\/jats:named-content>\n            . In patients with severe sepsis, a loading dose or continuous infusion and drug monitoring could improve the pharmacodynamic parameters associated with linezolid efficacy.\n          <\/jats:p>","DOI":"10.1128\/aac.01694-12","type":"journal-article","created":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T01:16:33Z","timestamp":1360718193000},"page":"1913-1917","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":52,"title":["Risk Factors for a Low Linezolid Trough Plasma Concentration in Acute Infections"],"prefix":"10.1128","volume":"57","author":[{"given":"Laura","family":"Morata","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Hospital Cl\u00ednic of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Cuesta","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Cl\u00ednic of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhon F.","family":"Rojas","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Cl\u00ednic of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Cl\u00ednic of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merce","family":"Brunet","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Hospital Cl\u00ednic of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregori","family":"Casals","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Hospital Cl\u00ednic of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazareth","family":"Cobos","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Cl\u00ednic of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Cl\u00ednic of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Cl\u00ednic of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Mensa","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Cl\u00ednic of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Soriano","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Cl\u00ednic of Barcelona, Barcelona, Spain"},{"name":"IDIBAPS, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg249"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70312-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir895"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(03)00065-5"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200342150-00007"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00177-10"},{"key":"e_1_3_3_8_2","first-page":"207","article-title":"Determinaci\u00f3n de linezolid en plasma mediante cromatograf\u00eda l\u00edquida de 11 alta resoluci\u00f3n para la monitorizaci\u00f3n terap\u00e9utica en pacientes","volume":"4","author":"Foj Capell L","year":"2011","unstructured":"Foj CapellL Soriano ViladomiuA Brunet SerraM L\u00f3pez GaleraRM. 2011. Determinaci\u00f3n de linezolid en plasma mediante cromatograf\u00eda l\u00edquida de 11 alta resoluci\u00f3n para la monitorizaci\u00f3n terap\u00e9utica en pacientes. Rev. Lab. Clin. 4:207\u2013213.","journal-title":"Rev. Lab. Clin."},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.09.009"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm431"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc9091"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2011.92"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-008-0587-2"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-010-0080-6"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/498509"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.04.017"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.8.2723-2726.2002"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.106.013755"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200511243532123"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1Q757"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2009.03.001"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks022"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq506"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01694-12","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01694-12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T22:23:34Z","timestamp":1645482214000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01694-12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1128\/AAC.01694-12"],"URL":"https:\/\/doi.org\/10.1128\/aac.01694-12","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"2012-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-03-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}