{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T21:45:22Z","timestamp":1648935922018},"reference-count":27,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We further examined the usefulness of previously reported\n            <jats:italic>Bacillus subtilis<\/jats:italic>\n            biosensors for antibacterial mode-of-action studies. The biosensors could not detect the tRNA synthetase inhibitors mupirocin, indolmycin, and borrelidin, some inhibitors of peptidoglycan synthesis, and most membrane-damaging agents. However, the biosensors confirmed the modes of action of several RNA polymerase inhibitors and DNA intercalators and provided new insights into the possible modes of action of ciprofloxacin, anhydrotetracycline, corralopyronin, 8-hydroxyquinoline, and juglone.\n          <\/jats:p>","DOI":"10.1128\/aac.01710-10","type":"journal-article","created":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T03:38:51Z","timestamp":1296531531000},"page":"1784-1786","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Further Characterization of\n            <i>Bacillus subtilis<\/i>\n            Antibiotic Biosensors and Their Use for Antibacterial Mode-of-Action Studies"],"prefix":"10.1128","volume":"55","author":[{"given":"Katherine R.","family":"Mariner","sequence":"first","affiliation":[{"name":"Antimicrobial Research Centre and Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Ooi","sequence":"additional","affiliation":[{"name":"Antimicrobial Research Centre and Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Roebuck","sequence":"additional","affiliation":[{"name":"Antimicrobial Research Centre and Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex J.","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Antimicrobial Research Centre and Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Chopra","sequence":"additional","affiliation":[{"name":"Antimicrobial Research Centre and Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1969.tb00579.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2010.48"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.3.767"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.138.3.923-932.1979"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1470401"},{"key":"e_1_3_2_7_2","unstructured":"The molecular basis of antibiotic action 2nd ed. 1981"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.3.1127-1134.2005"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn321"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.12.4821-4833.2005"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.5.1568-1570.2002"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00753-10"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.09.033"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.22.4.560"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.5.913"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.2.532-539.2001"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.2.458-466.2003"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh114"},{"key":"e_1_3_2_19_2","unstructured":"Reference deleted."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a123251"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp299"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp409"},{"key":"e_1_3_2_23_2","first-page":"1","volume":"27","year":"1991","unstructured":"Oxford University Press. 1991. 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