{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:59:22Z","timestamp":1787162362649,"version":"build-2736575974"},"reference-count":9,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Paratek Pharmaceuticals, Boston, MA"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2016,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n In vitro<\/jats:italic>\n activities of omadacycline, a new aminomethylcycline, were determined for\n Mycoplasma<\/jats:named-content>\n and\n Ureaplasma<\/jats:named-content>\n spp. and compared with those of azithromycin, clindamycin, moxifloxacin, tetracycline, and doxycycline. All omadacycline MICs were <2 \u03bcg\/ml. MIC\n 90<\/jats:sub>\n s were 0.063 \u03bcg\/ml for\n Mycoplasma hominis<\/jats:named-content>\n , 0.25 \u03bcg\/ml for\n Mycoplasma pneumoniae<\/jats:named-content>\n , and 2 \u03bcg\/ml for\n Ureaplasma<\/jats:named-content>\n spp. Omadacycline had the lowest MIC\n 90<\/jats:sub>\n among all drugs tested against\n M. hominis<\/jats:named-content>\n . Omadacycline activity was not affected by macrolide, tetracycline, or fluoroquinolone resistance.\n <\/jats:p>","DOI":"10.1128\/aac.01734-16","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T23:44:12Z","timestamp":1474933452000},"page":"7502-7504","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":39,"title":["In Vitro<\/i>\n Activities of Omadacycline (PTK 0796) and Other Antimicrobial Agents against Human Mycoplasmas and Ureaplasmas"],"prefix":"10.1128","volume":"60","author":[{"given":"Ken B.","family":"Waites","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"Crabb","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Antibiotics, Huashan Hospital, Institute of Biomedical Sciences, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn B.","family":"Duffy","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01242-13"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2016-0100"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01066-13"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.17.4.697-728.2004"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.4.757-789.2005"},{"key":"e_1_3_1_7_2","first-page":"289","volume-title":"Mollicutes molecular biology and pathogenesis","author":"Waites KB","year":"2014","unstructured":"Waites KB, Lysynyansky I, Bebear CM. 2014. Emerging antimicrobial resistance in mycoplasmas of humans and animals, p 289\u2013322. In Browning G, Citti C (ed), Mollicutes molecular biology and pathogenesis. Caister Academic Press, Norfolk, United Kingdom."},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2108.150273"},{"key":"e_1_3_1_9_2","volume-title":"CLSI document M43-A","author":"Clinical and Laboratory Standards Institute","year":"2011","unstructured":"Clinical and Laboratory Standards Institute. 2011. Methods for antimicrobial susceptibility testing of human mycoplasmas; approved guideline. CLSI document M43-A. Clinical and Laboratory Standards Institute, Wayne, PA."},{"key":"e_1_3_1_10_2","volume-title":"Coordinating ed, Nolte FS","author":"Waites KB","year":"2001","unstructured":"Waites KB, Bebear CM, Robertson JA, Talkington DF, Kenny GE. 2001. Cumitech 34, Laboratory diagnosis of mycoplasmal infections. Coordinating ed, Nolte FS. American Society for Microbiology, Washington, DC."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01734-16","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01734-16","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:30:41Z","timestamp":1645457441000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01734-16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":9,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1128\/AAC.01734-16"],"URL":"https:\/\/doi.org\/10.1128\/aac.01734-16","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"2016-08-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}