{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:16:12Z","timestamp":1791404172993,"version":"4.3.3"},"reference-count":14,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Aerobic (5-day-old cultures) and nonreplicating (dormant)\n            <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n            (5-, 12-, and 19-day-old cultures) bacteria were treated with rifampin (R), moxifloxacin (MX), metronidazole (MZ), amikacin (AK), or capreomycin (CP) for 7, 14, and 21 days. R-MX-MZ-AK and R-MX-MZ-CP killed both aerobic and dormant bacilli in 21 days, as shown by lack of regrowth in solid and liquid media. R-MX-MZ-AK and R-MX-MZ-CP also caused a strong decrease of nonreplicating bacilli in 7 days in a cell-based dormancy model.\n          <\/jats:p>","DOI":"10.1128\/aac.01736-09","type":"journal-article","created":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T03:55:06Z","timestamp":1269921306000},"page":"2712-2715","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["Activity of Drug Combinations against Dormant\n            <i>Mycobacterium tuberculosis<\/i>"],"prefix":"10.1128","volume":"54","author":[{"given":"Perla","family":"Filippini","sequence":"first","affiliation":[{"name":"Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanita\u0300, Via Regina Elena 299, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Iona","sequence":"additional","affiliation":[{"name":"Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanita\u0300, Via Regina Elena 299, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Piccaro","sequence":"additional","affiliation":[{"name":"Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanita\u0300, Via Regina Elena 299, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Peyron","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique"},{"name":"Universite\u0301 de Toulouse, Universite\u0301 Paul Sabatier, Institut de Pharmacologie et de Biologie Structurale, F-31077 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Neyrolles","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique"},{"name":"Universite\u0301 de Toulouse, Universite\u0301 Paul Sabatier, Institut de Pharmacologie et de Biologie Structurale, F-31077 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanfranco","family":"Fattorini","sequence":"additional","affiliation":[{"name":"Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanita\u0300, Via Regina Elena 299, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043383214"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2236"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00055-06"},{"key":"e_1_3_2_5_2","first-page":"9","volume":"31","year":"1993","unstructured":"Edwards, D. 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In vitro model of hypoxically induced nonreplicating persistence of Mycobacterium tuberculosis, p. 247-269. In T. Parish and N. Stoker (ed.), Methods in molecular medicine. Mycobacterium tuberculosis protocols. Humana Press, Totowa, NJ.","journal-title":"Methods in molecular medicine"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01736-09","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01736-09","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:17:54Z","timestamp":1645474674000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01736-09"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["10.1128\/AAC.01736-09"],"URL":"https:\/\/doi.org\/10.1128\/aac.01736-09","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6]]},"assertion":[{"value":"2009-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-03-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}