{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:20:09Z","timestamp":1777389609407,"version":"3.51.4"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Everest Medicines"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2023,5,17]]},"abstract":"<jats:p>\n            The objective was to determine the magnitude of the EVER206 free-plasma area under the concentration time curve (\n            <jats:italic>f<\/jats:italic>\n            AUC)\/MIC target associated with bacteriostasis and 1-log\n            <jats:sub>10<\/jats:sub>\n            kill against clinically relevant Gram-negative bacteria in the murine thigh model. Twenty-seven clinical isolates (\n            <jats:named-content content-type=\"genus-species\">Pseudomonas aeruginosa<\/jats:named-content>\n            ,\n            <jats:italic>n<\/jats:italic>\n            \u2009=\u200910;\n            <jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>\n            <jats:italic>, n<\/jats:italic>\n            \u2009=\u20099;\n            <jats:named-content content-type=\"genus-species\">Klebsiella pneumoniae<\/jats:named-content>\n            ,\n            <jats:italic>n<\/jats:italic>\n            \u2009=\u20095;\n            <jats:named-content content-type=\"genus-species\">Enterobacter cloacae<\/jats:named-content>\n            ,\n            <jats:italic>n<\/jats:italic>\n            \u2009=\u20092; and\n            <jats:named-content content-type=\"genus-species\">Klebsiella aerogenes<\/jats:named-content>\n            ,\n            <jats:italic>n<\/jats:italic>\n            \u2009=\u20091) were tested.\n          <\/jats:p>","DOI":"10.1128\/aac.01738-22","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T14:04:27Z","timestamp":1680789867000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["<i>In Vivo<\/i>\n            Pharmacodynamic Profile of EVER206, a Novel Polymyxin Antimicrobial, against Gram-Negative Bacteria in the Murine Thigh Infection Model"],"prefix":"10.1128","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3606-0761","authenticated-orcid":true,"given":"Christian M.","family":"Gill","sequence":"first","affiliation":[{"name":"Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4148-0165","authenticated-orcid":true,"given":"David P.","family":"Nicolau","sequence":"additional","affiliation":[{"name":"Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA"},{"name":"Division of Infectious Diseases, Hartford Hospital, Hartford, Connecticut, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2011.12.006"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2209"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.9b00217"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00739-21"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaa217"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/510079"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01114-09"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv267"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx409"},{"key":"e_1_3_3_11_2","unstructured":"McEntee L Johnson A Farrington N Kirby A Lister T Parr T Controneo N Das S Hope W. 2019. 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