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We evaluated a series of 12 synthetic compounds for antiparasitic activity against\n                      <jats:italic toggle=\"yes\">Schistosoma mansoni<\/jats:italic>\n                      adult worms\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      . Isoindole-1,3-dione derivatives were inactive, whereas four imidazolidine-2,4-dione derivatives displayed selective antischistosomal activity with low cytotoxicity in mammalian cells. These findings highlight imidazolidine-2,4-dione as a promising scaffold for the development of new therapeutic agents against schistosomiasis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.01748-25","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T13:00:36Z","timestamp":1769432436000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Antischistosomal activity of imidazolidine-2,4-dione derivatives"],"prefix":"10.1128","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7921-8007","authenticated-orcid":true,"given":"Anna","family":"Jaromin","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00yae6e25","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Lipids and Liposomes, Faculty of Biotechnology, University of Wroc\u0142aw","place":["Wroc\u0142aw, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1448-9826","authenticated-orcid":false,"given":"Anna","family":"Czopek","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03bqmcz70","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medicinal Chemistry, Jagiellonian University Medical College","place":["Cracow, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thain\u00e1 R.","family":"Teixeira","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01rx63s97","id-type":"ROR","asserted-by":"publisher"}],"name":"Research Center on Neglected Diseases, Guarulhos University","place":["Guarulhos, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Zag\u00f3rska","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03bqmcz70","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medicinal Chemistry, Jagiellonian University Medical College","place":["Cracow, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1766-7031","authenticated-orcid":true,"given":"Josu\u00e9","family":"de Moraes","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01rx63s97","id-type":"ROR","asserted-by":"publisher"}],"name":"Research Center on Neglected Diseases, Guarulhos University","place":["Guarulhos, Brazil"]},{"name":"Research Center on Neglected Diseases, Scientific and Technological Institute, Brazil University","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)00768-8"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-02792-0"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2022.2051477"},{"key":"e_1_3_4_5_2","volume-title":"Ending the neglect to attain the sustainable development goals: a road map for neglected tropical diseases 2021\u20132030","author":"World Health Organization","year":"2020","unstructured":"World Health Organization. 2020. 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