{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:36:03Z","timestamp":1788849363295,"version":"build-2803163510"},"reference-count":40,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Karl Landsteiner Gesellschaft"},{"name":"Federal Ministry of Science, Research, and Economy of Austria as part of the EDCTP-2 program supported by the European Union"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2018,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Treatment recommendations for\n Plasmodium malariae<\/jats:named-content>\n and\n Plasmodium ovale<\/jats:named-content>\n malaria are largely based on anecdotal evidence. The aim of this prospective study, conducted in Gabon, was to systematically assess the efficacy and safety of artemether-lumefantrine for the treatment of patients with uncomplicated\n P. malariae<\/jats:named-content>\n or\n P. ovale<\/jats:named-content>\n species monoinfections or mixed\n Plasmodium<\/jats:named-content>\n infections. Patients with microscopically confirmed\n P. malariae<\/jats:named-content>\n ,\n P. ovale<\/jats:named-content>\n , or mixed-species malaria with at least one of these two\n Plasmodium<\/jats:named-content>\n species were treated with an oral, fixed-dose combination of artemether-lumefantrine for 3 consecutive days. The primary endpoints were per-protocol PCR-corrected adequate clinical and parasitological response (ACPR) on days 28 and 42. Tolerability and safety were recorded throughout the follow-up period. Seventy-two participants (42 male and 30 female) were enrolled; 62.5% of them had PCR-corrected mixed\n Plasmodium<\/jats:named-content>\n infections. Per protocol, PCR-corrected ACPR rates were 96.6% (95% confidence interval [CI], 91.9 to 100) on day 28 and 94.2% (95% CI, 87.7 to 100) on day 42. Considering\n Plasmodium<\/jats:named-content>\n species independently from their coinfecting species, day 42 ACPR rates were 95.5% (95% CI, 89.0 to 100) for\n P. falciparum<\/jats:named-content>\n , 100% (exact CI, 84.6 to 100) for\n P. malariae<\/jats:named-content>\n , 100% (exact CI, 76.8 to 100) for\n P. ovale curtisi<\/jats:named-content>\n , and 90.9% (95% CI, 70.7 to 100) for\n P. ovale wallikeri<\/jats:named-content>\n . Study drug-related adverse events were generally mild or moderate. In conclusion, this clinical trial demonstrated satisfying antimalarial activity of artemether-lumefantrine against\n P. ovale<\/jats:named-content>\n wallikeri<\/jats:italic>\n ,\n P. ovale curtisi<\/jats:named-content>\n ,\n P. malariae<\/jats:named-content>\n , and mixed\n Plasmodium<\/jats:named-content>\n infections, with per-protocol efficacies of 90% to 100% and without evident tolerability or safety concerns. (This trial was registered in the clinical study database ClinicalTrials.gov under the identifier NCT02528279.)\n <\/jats:p>","DOI":"10.1128\/aac.01758-17","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T12:04:47Z","timestamp":1515413087000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":30,"title":["Prospective Clinical Trial Assessing Species-Specific Efficacy of Artemether-Lumefantrine for the Treatment of Plasmodium malariae, Plasmodium ovale, and Mixed Plasmodium Malaria in Gabon"],"prefix":"10.1128","volume":"62","author":[{"given":"Mirjam","family":"Groger","sequence":"first","affiliation":[{"name":"Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria"},{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, Lambar\u00e9n\u00e9, Gabon"},{"name":"Centre de Recherches M\u00e9dicales de la Ngounie, Fougamou, Gabon"},{"name":"Institut f\u00fcr Tropenmedizin, Universit\u00e4t T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luzia","family":"Veletzky","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria"},{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, Lambar\u00e9n\u00e9, Gabon"},{"name":"Centre de Recherches M\u00e9dicales de la Ngounie, Fougamou, Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Lalremruata","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Tropenmedizin, Universit\u00e4t T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, 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