{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T14:34:47Z","timestamp":1774276487900,"version":"3.50.1"},"reference-count":12,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We compared the abilities of structurally related cationic cyclodextrins to inhibit\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Bacillus anthracis<\/jats:named-content>\n            lethal toxin and\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Staphylococcus aureus<\/jats:named-content>\n            \u03b1-hemolysin. We found that both \u03b2- and \u03b3-cyclodextrin derivatives effectively inhibited anthrax toxin action by blocking the transmembrane oligomeric pores formed by the protective antigen (PA) subunit of the toxin, whereas \u03b1-cyclodextrins were ineffective. In contrast, \u03b1-hemolysin was selectively blocked only by \u03b2-cyclodextrin derivatives, demonstrating that both symmetry and size of the inhibitor and the pore are important.\n          <\/jats:p>","DOI":"10.1128\/aac.01764-10","type":"journal-article","created":{"date-parts":[[2011,5,10]],"date-time":"2011-05-10T05:02:15Z","timestamp":1305003735000},"page":"3594-3597","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":30,"title":["Symmetry Requirements for Effective Blocking of Pore-Forming Toxins: Comparative Study with \u03b1-, \u03b2-, and \u03b3-Cyclodextrin Derivatives"],"prefix":"10.1128","volume":"55","author":[{"given":"Konstantina","family":"Yannakopoulou","sequence":"first","affiliation":[{"name":"Institute of Physical Chemistry, National Center for Scientific Research Demokritos, Aghia Paraskevi 15310, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laszlo","family":"Jicsinszky","sequence":"additional","affiliation":[{"name":"CYCLOLAB R&amp;D Laboratories Ltd., Illatos ut. 7, H-1097 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crysie","family":"Aggelidou","sequence":"additional","affiliation":[{"name":"Institute of Physical Chemistry, National Center for Scientific Research Demokritos, Aghia Paraskevi 15310, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Mourtzis","sequence":"additional","affiliation":[{"name":"Institute of Physical Chemistry, National Center for Scientific Research Demokritos, Aghia Paraskevi 15310, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanisha M.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Innovative Biologics, Inc., 13455 Sunrise Valley Dr., Suite 200, Herndon, Virginia 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