{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:44:17Z","timestamp":1791531857852,"version":"4.3.4"},"reference-count":17,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>In vitro<\/jats:italic>\n            double and triple bactericidal activities of doripenem, polymyxin B, and rifampin were assessed against 20 carbapenem-resistant clinical isolates with different mechanisms of carbapenem resistance. Bactericidal activity was achieved in 90% of all bacteria assayed using combinations of polymyxin B, doripenem, and rifampin against five each of the carbapenem-resistant\n            <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n            ,\n            <jats:italic>Acinetobacter baumannii<\/jats:italic>\n            ,\n            <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n            , and\n            <jats:italic>Escherichia coli<\/jats:italic>\n            isolates studied. Combinations with these antibacterials may provide a strategy for treatment of patients infected with such organisms.\n          <\/jats:p>","DOI":"10.1128\/aac.01768-09","type":"journal-article","created":{"date-parts":[[2010,4,6]],"date-time":"2010-04-06T00:27:25Z","timestamp":1270513645000},"page":"2732-2734","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":88,"title":["<i>In Vitro<\/i>\n            Double and Triple Bactericidal Activities of Doripenem, Polymyxin B, and Rifampin against Multidrug-Resistant\n            <i>Acinetobacter baumannii<\/i>\n            ,\n            <i>Pseudomonas aeruginosa<\/i>\n            ,\n            <i>Klebsiella pneumoniae<\/i>\n            , and\n            <i>Escherichia coli<\/i>"],"prefix":"10.1128","volume":"54","author":[{"given":"Carl","family":"Urban","sequence":"first","affiliation":[{"name":"Infectious Disease Section, New York Hospital Queens, Flushing, New York"},{"name":"Departments of Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriel","family":"Mariano","sequence":"additional","affiliation":[{"name":"Infectious Disease Section, New York Hospital Queens, Flushing, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Rahal","sequence":"additional","affiliation":[{"name":"Infectious Disease Section, New York Hospital Queens, Flushing, New York"},{"name":"Medicine, Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/421495"},{"key":"e_1_3_2_3_2","first-page":"128","volume":"56","year":"2005","unstructured":"Bratu, S., P. Tolaney, U. Karumudi, J. Quale, M. Mooty, S. Nichani, and D. Landman. 2005. Carbapenemase-producing Klebsiella pneumoniae in Brooklyn, NY: molecular epidemiology and in vitro activity of polymyxin B and other agents. J. Antimicrob. Agents56:128-132.","journal-title":"J. Antimicrob. Agents"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(98)00060-0"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2006.07.004"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/600042"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2006.01.019"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2004.12.008"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.4.1313-1319.2004"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.12.6.655"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/522287"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2008.02061.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01004-09"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00001-07"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1086\/504486","volume":"43","year":"2006","unstructured":"Rahal, J. J. 2006. Novel antibiotic combinations against infections with almost completely resistant Pseudomonas aeruginosa and Acinetobacter species. Clin. Infect. Dis.43(Suppl. 2):S95-S99.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.revmedmi.0000131426.36224.82"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/588048"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.3.753-757.2004"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01768-09","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01768-09","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:16:56Z","timestamp":1645474616000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01768-09"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["10.1128\/AAC.01768-09"],"URL":"https:\/\/doi.org\/10.1128\/aac.01768-09","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6]]},"assertion":[{"value":"2009-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-03-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}