{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T01:07:26Z","timestamp":1782349646609,"version":"3.54.5"},"reference-count":47,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            An insertional mutation made in the major cold shock gene\n            <jats:italic>cspB<\/jats:italic>\n            in\n            <jats:italic>Staphylococcus<\/jats:italic>\n            <jats:italic>aureus<\/jats:italic>\n            strain COL, a methicillin-resistant clinical isolate, yielded a mutant that displayed a reduced capacity to respond to cold shock and many phenotypic characteristics of\n            <jats:italic>S<\/jats:italic>\n            .\n            <jats:italic>aureus<\/jats:italic>\n            small-colony variants: a growth defect at 37\u00b0C, a reduction in pigmentation, and altered levels of susceptibility to many antimicrobials. In particular, a\n            <jats:italic>cspB<\/jats:italic>\n            null mutant displayed increased resistance to aminoglycosides, trimethoprim-sulfamethoxazole, and paraquat and increased susceptibility to daptomycin, teicoplanin, and methicillin. With the exception of the increased susceptibility to methicillin, which was due to a complete loss of the type I staphylococcal cassette chromosome\n            <jats:italic>mec<\/jats:italic>\n            element, these properties were restored to wild-type levels by complementation when\n            <jats:italic>cspB<\/jats:italic>\n            was expressed in\n            <jats:italic>trans<\/jats:italic>\n            . Taken together, our results link a stress response protein (CspB) of\n            <jats:italic>S<\/jats:italic>\n            .\n            <jats:italic>aureus<\/jats:italic>\n            to important phenotypic properties that include resistance to certain antimicrobials.\n          <\/jats:p>","DOI":"10.1128\/aac.01786-09","type":"journal-article","created":{"date-parts":[[2010,4,6]],"date-time":"2010-04-06T00:27:25Z","timestamp":1270513645000},"page":"2283-2290","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":39,"title":["Altered Growth, Pigmentation, and Antimicrobial Susceptibility Properties of\n            <i>Staphylococcus<\/i>\n            <i>aureus<\/i>\n            Due to Loss of the Major Cold Shock Gene\n            <i>cspB<\/i>"],"prefix":"10.1128","volume":"54","author":[{"given":"Brea D.","family":"Duval","sequence":"first","affiliation":[{"name":"Departments of Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anselmo","family":"Mathew","sequence":"additional","affiliation":[{"name":"Departments of Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah W.","family":"Satola","sequence":"additional","affiliation":[{"name":"Medicine, Emory University School of Medicine, Atlanta, Georgia 30322"},{"name":"Emerging Infections Program, VA Medical Center Research Service, VA Medical Center (Atlanta), Decatur, Georgia 30033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Shafer","sequence":"additional","affiliation":[{"name":"Departments of Microbiology and Immunology"},{"name":"Laboratory of Bacterial Pathogenesis and Antimicrobial Resistance"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00609-06"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1990.tb03997.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(74)90439-1"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.14.7784"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1097(97)00116-X"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.6.1220"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2200"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01444-06"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-145-10-2967"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.32.5.788"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2005.01236.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.32.2.279"},{"key":"e_1_3_2_14_2","first-page":"835","volume":"1","year":"1966","unstructured":"Dyke, K. 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