{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:39:20Z","timestamp":1792798760214,"version":"4.5.0"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T00:00:00Z","timestamp":1611100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Innovative Medicines Initiative (IMI) Joint Undertaking European Union Seventh Framework Program and EFPIA Companies","award":["115525 ND4BB Translocation"],"award-info":[{"award-number":["115525 ND4BB Translocation"]}],"id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2021,1,20]]},"abstract":"<jats:p>\n                    Inactivating\n                    <jats:italic>tolC<\/jats:italic>\n                    in multidrug-resistant\n                    <jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>\n                    with differing sequence types and quinolone resistance-determining mutations reveals remarkably potentiated activity of the first-in-class topoisomerase inhibitors gepotidacin and zoliflodacin. Differences between both structurally unrelated compounds in comparison to fluoroquinolones regarding the selectivity of\n                    <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n                    RND (resistance-nodulation-cell division)-type transporters, efflux inhibitors, and AcrB porter domain mutations were demonstrated.\n                  <\/jats:p>","DOI":"10.1128\/aac.01803-20","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T09:02:37Z","timestamp":1605517357000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["New Topoisomerase Inhibitors: Evaluating the Potency of Gepotidacin and Zoliflodacin in Fluoroquinolone-Resistant Escherichia coli upon\n                    <i>tolC<\/i>\n                    Inactivation and Differentiating Their Efflux Pump Substrate Nature"],"prefix":"10.1128","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8817-6224","authenticated-orcid":false,"given":"Sabine","family":"Schuster","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine II, University Hospital and Medical Center, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Vavra","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine II, University Hospital and Medical Center, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"K\u00f6ser","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine II, University Hospital and Medical Center, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W. 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