{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:58:17Z","timestamp":1790506697386,"version":"4.1.0"},"reference-count":76,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100003074","name":"MINCyT | Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2017 no. 0950"],"award-info":[{"award-number":["PICT 2017 no. 0950"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP 2016 no. 11220150100406"],"award-info":[{"award-number":["PIP 2016 no. 11220150100406"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002745","name":"Bayerische Forschungsstiftung","doi-asserted-by":"publisher","award":["AZ-1341-18"],"award-info":[{"award-number":["AZ-1341-18"]}],"id":[{"id":"10.13039\/501100002745","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007070","name":"Universidad Nacional de Mar del Plata","doi-asserted-by":"publisher","award":["EXA 862\/18"],"award-info":[{"award-number":["EXA 862\/18"]}],"id":[{"id":"10.13039\/501100007070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007070","name":"Universidad Nacional de Mar del Plata","doi-asserted-by":"publisher","award":["EXA863\/18"],"award-info":[{"award-number":["EXA863\/18"]}],"id":[{"id":"10.13039\/501100007070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,8,20]]},"abstract":"<jats:p>\n                    Alveolar echinococcosis (AE) is a severe disease caused by the larval stage of the tapeworm\n                    <jats:named-content content-type=\"genus-species\">Echinococcus multilocularis<\/jats:named-content>\n                    . Current chemotherapeutic treatment options based on benzimidazoles are of limited effectiveness, which underlines the need to find new antiechinococcosis drugs. Metformin is an antihyperglycemic and antiproliferative agent that shows activity against the related parasite\n                    <jats:named-content content-type=\"genus-species\">Echinococcus granulosus<\/jats:named-content>\n                    . Hence, we assessed the\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    effects of the drug on\n                    <jats:named-content content-type=\"genus-species\">E. multilocularis<\/jats:named-content>\n                    .\n                  <\/jats:p>","DOI":"10.1128\/aac.01808-19","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T10:15:33Z","timestamp":1591870533000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Metformin Suppresses Development of the Echinococcus multilocularis Larval Stage by Targeting the TOR Pathway"],"prefix":"10.1128","volume":"64","author":[{"given":"Julia A.","family":"Loos","sequence":"first","affiliation":[{"name":"Laboratorio de Zoonosis Parasitarias, Departamento de Biolog\u00eda, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP), Mar del Plata, Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Mar del Plata, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria A.","family":"D\u00e1vila","sequence":"additional","affiliation":[{"name":"Laboratorio de Zoonosis Parasitarias, Departamento de Biolog\u00eda, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP), Mar del Plata, Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Mar del Plata, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Brehm","sequence":"additional","affiliation":[{"name":"University of W\u00fcrzburg, Institute of Hygiene and Microbiology, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea C.","family":"Cumino","sequence":"additional","affiliation":[{"name":"Laboratorio de Zoonosis Parasitarias, Departamento de Biolog\u00eda, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP), Mar del Plata, Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Mar del Plata, Argentina"},{"name":"Departamento de Qu\u00edmica, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP), Mar del Plata, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(01)00424-1"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apar.2016.11.001"},{"key":"e_1_3_3_4_2","first-page":"525","volume-title":"Echinococcus and echinococcosis","author":"Thompson A","year":"2017","unstructured":"Thompson A, Deplazes P, Lymbery AJ. 2017. Echinococcus and echinococcosis. Part A, vol. 95, Academic Press, San Diego, CA. p. 525."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/zph.12326"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apar.2016.09.006"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/2041-9139-5-10"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00075-18"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02569-12"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fawpar.2019.e00040"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2018.10.011"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31541-1"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.181"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2975"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-2994"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16149-z"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29895-5"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1120781"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.09.018"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.09.013"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.01.003"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.03.003"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-2229"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2009.08.007"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0244-7"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2672"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.03.178"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.09.003"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126009"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005370"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2014.02.007"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2018.07.003"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2007.11.002"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-016-1687-y"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-010-0154-1"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00232a015"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2011.86"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2012.13"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2013.03.009"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-12-5"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2009.11.011"},{"key":"e_1_3_3_42_2","first-page":"3504","article-title":"A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells","volume":"60","author":"Sekuli\u0107 A","year":"2000","unstructured":"Sekuli\u0107 A, Hudson CC, Homme JL, Yin P, Otterness DM, Karnitz LM, Abraham RT. 2000. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res 60:3504\u20133513.","journal-title":"Cancer Res"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11016"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3440427"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C300534200"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature25023"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00278590"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-204-5_17"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12596"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0065-308x(02)51005-8"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2018.07.006"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11808"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/celldisc.2017.10"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.02242"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002870"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/2014070"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2012.07.007"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2018.04.002"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-013-1845-x"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.2165\/11534750-000000000-00000"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.3109\/00498259409043220"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00378-07"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12031"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-019-06421-8"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0020-7519(02)00265-5"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-3014"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006959"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2757"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00427-019-00632-w"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.31268"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001897"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1221055110"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.07.030"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/54004230"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0087-6"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.64.070195.001443"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5338.631"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01808-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01808-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T17:01:10Z","timestamp":1645462870000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01808-19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,20]]},"references-count":76,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,8,20]]}},"alternative-id":["10.1128\/AAC.01808-19"],"URL":"https:\/\/doi.org\/10.1128\/aac.01808-19","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,20]]},"assertion":[{"value":"2019-09-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01808-19"}}