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The 23S rRNA mutation and\n            <jats:italic>erm<\/jats:italic>\n            (X) gene are known as the major resistance determinants of macrolides and clindamycin in\n            <jats:italic>C. acnes<\/jats:italic>\n            . We isolated eight high-level macrolide-clindamycin-resistant\n            <jats:italic>C. acnes<\/jats:italic>\n            strains with no known resistance determinants, such as 23S rRNA mutation and\n            <jats:italic>erm<\/jats:italic>\n            (X), from different acne patients in 2008 between 2013 and 2015.\n          <\/jats:p>","DOI":"10.1128\/aac.01810-19","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T12:59:57Z","timestamp":1576501197000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["Transferable Multidrug-Resistance Plasmid Carrying a Novel Macrolide-Clindamycin Resistance Gene,\n            <i>erm<\/i>\n            (50), in Cutibacterium acnes"],"prefix":"10.1128","volume":"64","author":[{"given":"Sae","family":"Aoki","sequence":"first","affiliation":[{"name":"Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9205-3008","authenticated-orcid":false,"given":"Keisuke","family":"Nakase","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2889-8257","authenticated-orcid":false,"given":"Hidemasa","family":"Nakaminami","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9506-707X","authenticated-orcid":false,"given":"Takeaki","family":"Wajima","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobukazu","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Toranomon Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihisa","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.01.027"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2014.02.004"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13027-016-0084-7"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9397"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12594"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14355"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000875"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/49.1.165"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05067.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2016.05.005"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.067611-0"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13913"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2011.01423.x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.4.836-871.2001"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046390"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00939-12"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.7.1702"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000392"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00358-17"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks428"},{"key":"e_1_3_2_22_2","volume-title":"Approved standard M100-S20","author":"CLSI","year":"2009","unstructured":"CLSI. 2009. 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