{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:41:30Z","timestamp":1785415290810,"version":"3.56.0"},"reference-count":28,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Young Scientists Fund of Hunan Provincial Natural Science Foundation","award":["2023JJ40802"],"award-info":[{"award-number":["2023JJ40802"]}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation of China","doi-asserted-by":"crossref","award":["2024JJ5465"],"award-info":[{"award-number":["2024JJ5465"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104306"],"award-info":[{"award-number":["82104306"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hunan Provincial Postgraduate Research Innovation Project","award":["CX20250145"],"award-info":[{"award-number":["CX20250145"]}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2025J011419"],"award-info":[{"award-number":["2025J011419"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2026,6,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Ceftazidime is widely used off-label to treat neonatal infections, underscoring the need for optimized dosing strategies. However, pharmacokinetic (PK) studies in neonates are limited by the challenges of conventional blood sampling. This study applied dried blood spot (DBS) micro-sampling to develop a population PK (PopPK) model to support appropriate ceftazidime dosing regimens in neonates. A prospective PopPK study was conducted in neonates receiving ceftazidime. Blood samples were collected using the Capitainer quantitative DBS (qDBS) device, and concentrations were quantified by ultra-performance liquid chromatography\u2013tandem mass spectrometry (UPLC\u2013MS\/MS). PopPK modeling was performed in NONMEM. Body weight (WT) and postmenstrual age (PMA) were incorporated a priori using allometric scaling and a sigmoidal maturation function. Additional covariates were evaluated using stepwise selection. Monte Carlo simulations were conducted to assess the probability of target attainment (PTA) for various dosing regimens against the target of 70% fT &gt; MIC. A total of 140 qDBS samples from 72 neonates were analyzed. A one-compartment model adequately described ceftazidime PK. PMA significantly influenced clearance, while WT affected volume of distribution. Simulations indicated that, for neonates with PMA 32\u201342 weeks, regimens of 25 mg\/kg every 6 or 8 h, and 75 mg\/kg every 12 h achieved a PTA \u226590% for MIC \u22644 mg\/L. A PopPK model for ceftazidime was successfully developed using qDBS samples from neonates. For neonates with PMA 32\u201342 weeks, dosing regimens of 25 mg\/kg every 6 or 8 h and 75 mg\/kg every 12 h are recommended to achieve optimal target attainment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.01810-25","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T10:00:21Z","timestamp":1776679221000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Population pharmacokinetic modeling and simulation-informed ceftazidime dosing in Chinese neonates using quantitative dried blood spot micro-sampling"],"prefix":"10.1128","volume":"70","author":[{"given":"Qiufen","family":"Yin","sequence":"first","affiliation":[{"name":"Division of Biopharmaceutics and Pharmacokinetics, Xiangya School of Pharmaceutical Sciences, Central South University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Chen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00mcjh785","id-type":"ROR","asserted-by":"publisher"}],"name":"Clinical Trial Institution, Scientific Research and lnnovation Center, Women and Children\u2019s Hospital, School of Medicine, Xiamen University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmei","family":"Lv","sequence":"additional","affiliation":[{"name":"Division of Biopharmaceutics and Pharmacokinetics, Xiangya School of Pharmaceutical Sciences, Central South University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Zheng","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00mcjh785","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neonatology, Women and Children\u2019s Hospital, School of Medicine, Xiamen University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zhao","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00mcjh785","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neonatology, Women and Children\u2019s Hospital, School of Medicine, Xiamen University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huayan","family":"Chen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00mcjh785","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neonatology, Women and Children\u2019s Hospital, School of Medicine, Xiamen University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9038-2676","authenticated-orcid":true,"given":"Feifan","family":"Xie","sequence":"additional","affiliation":[{"name":"Division of Biopharmaceutics and Pharmacokinetics, Xiangya School of Pharmaceutical Sciences, Central South University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6719-9788","authenticated-orcid":true,"given":"Hanxi","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Basic Medical Science, Central South University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4408-2565","authenticated-orcid":false,"given":"Quanyao","family":"Chen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00mcjh785","id-type":"ROR","asserted-by":"publisher"}],"name":"Clinical Trial Institution, Scientific Research and lnnovation Center, Women and Children\u2019s Hospital, School of Medicine, Xiamen University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(21)00311-4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2010.531330"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02486-17"},{"key":"e_1_3_3_5_2","first-page":"439","article-title":"Ceftazidime pharmacokinetics in preterm infants: effect of postnatal age and postnatal exposure to indomethacin","volume":"40","author":"van den Anker JN","year":"1995","unstructured":"van den Anker JN, Hop WC, Schoemaker RC, van der Heijden BJ, Neijens HJ, de Groot R. 1995. 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