{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:03:09Z","timestamp":1791414189201,"version":"4.3.3"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The activity of CEM-101, a fluoroketolide, was compared to those of 11 other antimicrobial agents using the reference broth microdilution method tested against 103\n            <jats:italic>Neisseria meningitidis<\/jats:italic>\n            strains, including ciprofloxacin-nonsusceptible isolates with confirmed\n            <jats:italic>gyr<\/jats:italic>\n            <jats:italic>A<\/jats:italic>\n            (T91I) mutations. Among the tested isolates, 79.6% were serogroup B or C and all isolates were susceptible to ceftriaxone, azithromycin, minocycline, and rifampin. However, penicillin-nonsusceptible strains were observed (15.5%) and susceptibility to trimethoprim-sulfamethoxazole was only 50.5%. CEM-101 was the most active macrolide-like compound (MIC\n            <jats:sub>90<\/jats:sub>\n            , \u22640.015 \u03bcg\/ml) compared with MIC\n            <jats:sub>90<\/jats:sub>\n            s of telithromycin (MIC\n            <jats:sub>90<\/jats:sub>\n            , 0.03 \u03bcg\/ml), azithromycin and clarithromycin (MIC\n            <jats:sub>90<\/jats:sub>\n            , 0.12 \u03bcg\/ml), and erythromycin (MIC\n            <jats:sub>90<\/jats:sub>\n            , 0.25 \u03bcg\/ml). CEM-101 could provide a potent alternative for the prophylaxis of meningococcal disease.\n          <\/jats:p>","DOI":"10.1128\/aac.01812-09","type":"journal-article","created":{"date-parts":[[2010,7,13]],"date-time":"2010-07-13T03:59:24Z","timestamp":1278993564000},"page":"4009-4011","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["Determination of CEM-101 Activity Tested against Clinical Isolates of\n            <i>Neisseria meningitidis<\/i>\n            from a Worldwide Collection"],"prefix":"10.1128","volume":"54","author":[{"given":"Douglas J.","family":"Biedenbach","sequence":"first","affiliation":[{"name":"JMI Laboratories, North Liberty, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Castanheira","sequence":"additional","affiliation":[{"name":"JMI Laboratories, North Liberty, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald N.","family":"Jones","sequence":"additional","affiliation":[{"name":"JMI Laboratories, North Liberty, Iowa"},{"name":"Tufts University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh075"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/377739"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1975.03240220015012"},{"key":"e_1_3_2_5_2","first-page":"173","volume":"57","year":"2008","unstructured":"Centers for Disease Control and Prevention. 2008. Emergence of fluoroquinolone-resistant Neisseria meningitidis\u2014Minnesota and North Dakota, 2007-2008. MMWR Morb. Mortal. Wkly. Rep.57:173-175.","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.11.028"},{"key":"e_1_3_2_7_2","unstructured":"Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard\u2014eighth edition. 2009"},{"key":"e_1_3_2_8_2","unstructured":"Performance standards for antimicrobial susceptibility testing. 2009"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki048"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.12.3877-3880.2003"},{"key":"e_1_3_2_11_2","first-page":"286","volume":"61","year":"2008","unstructured":"Enriquez, R., R. Abad, C. Salcedo, S. Perez, and J. A. Vazquez. 2008. Fluoroquinolone resistance in Neisseria meningitidis in Spain. J. Antimicrob. Chemother.61:286-290.","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000239553"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199809000-00013"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1511.090833"},{"key":"e_1_3_2_15_2","unstructured":"Intersci. Conf. Antimicrob. Agents Chemother. (ICAAC)-Infect. Dis. Soc. Am. (IDSA) 46th Annu. 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