{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:48:46Z","timestamp":1770482926831,"version":"3.49.0"},"reference-count":12,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Relative to the cefotaxime-gentamicin combination, the moxifloxacin-cefotaxime combination significantly reduced microglial activation and immature oligodendrocyte cell death and delayed myelination in the developing white matter of neonatal rats with experimental\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Escherichia coli<\/jats:named-content>\n            sepsis. These neuroprotective effects were not due to differences in\n            <jats:italic>in vivo<\/jats:italic>\n            bactericidal activities or in the systemic inflammatory responses and could be related to the intrinsic immunomodulatory properties of moxifloxacin. Molecular mechanisms underlying the neuroprotective effect of moxifloxacin remain to be elucidated.\n          <\/jats:p>","DOI":"10.1128\/aac.01813-10","type":"journal-article","created":{"date-parts":[[2011,4,19]],"date-time":"2011-04-19T04:25:10Z","timestamp":1303187110000},"page":"3567-3569","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Moxifloxacin Combined with Cefotaxime Compared to Cefotaxime-Gentamicin Combination on Prevention of White Matter Damage Associated with Escherichia coli Sepsis in Neonatal Rats"],"prefix":"10.1128","volume":"55","author":[{"given":"Nolwenn","family":"Le Sach\u00e9","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Diderot, Equipe d'Accueil EA 3105, F-75019 Paris, France"},{"name":"INSERM, AVENIR R05230HS, F-75019 Paris, 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