{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:01:46Z","timestamp":1785402106883,"version":"3.56.0"},"reference-count":30,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100009980","name":"Medical University of Innsbruck","doi-asserted-by":"publisher","award":["MUI D155-110-017-016"],"award-info":[{"award-number":["MUI D155-110-017-016"]}],"id":[{"id":"10.13039\/501100009980","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ISHAM Working Group Funding-Winter Call 2025","award":["A. terreus Working Group 2025-ISHAM"],"award-info":[{"award-number":["A. terreus Working Group 2025-ISHAM"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2026,6,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      This study assessed whether voriconazole (VRC) gradient diffusion results can be extrapolated to isavuconazole (ISA) and posaconazole (PSC) in\n                      <jats:italic toggle=\"yes\">Aspergillus fumigatus<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Aspergillus terreus<\/jats:italic>\n                      by comparison with the Clinical and Laboratory Standards Institute (CLSI) broth microdilution (BMD) and\n                      <jats:italic toggle=\"yes\">cyp51A<\/jats:italic>\n                      sequencing. Agreement with CLSI BMD was highest at 48 h, but remained limited for some azole-species combinations. VRC-PSC extrapolation was reliable in both species, whereas VRC-ISA extrapolation was species-dependent. Gradient diffusion underestimated resistance detection in some\n                      <jats:italic toggle=\"yes\">cyp51A<\/jats:italic>\n                      -mutant isolates, highlighting the risk of false-susceptible interpretations.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.01813-25","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:23:32Z","timestamp":1778855012000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Can voriconazole gradient diffusion testing results be extrapolated to isavuconazole and posaconazole in\n                    <i>Aspergillus<\/i>\n                    spp.? Comparative analysis with CLSI broth microdilution and\n                    <i>cyp51A<\/i>\n                    gene sequencing"],"prefix":"10.1128","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7518-7795","authenticated-orcid":true,"given":"Roya","family":"Vahedi-Shahandashti","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03pt86f80","id-type":"ROR","asserted-by":"publisher"}],"name":"European Confederation of Medical Mycology (ECMM) Excellence Center, Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck","place":["Innsbruck, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Sophia","family":"Nickel","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03pt86f80","id-type":"ROR","asserted-by":"publisher"}],"name":"European Confederation of Medical Mycology (ECMM) Excellence Center, Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck","place":["Innsbruck, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4428-3241","authenticated-orcid":false,"given":"David","family":"Eisele","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03pt86f80","id-type":"ROR","asserted-by":"publisher"}],"name":"European Confederation of Medical Mycology (ECMM) Excellence Center, Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck","place":["Innsbruck, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2946-7785","authenticated-orcid":true,"given":"Cornelia","family":"Lass-Fl\u00f6rl","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03pt86f80","id-type":"ROR","asserted-by":"publisher"}],"name":"European Confederation of Medical Mycology (ECMM) Excellence Center, Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck","place":["Innsbruck, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of ISHAM Working Group Member of Intrinsic Antifungal Resistance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00140-18"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof3040057"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00692-8"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms13061218"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2019.103247"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw326"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof2030025"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00516"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof2030021"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.01141-23"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaf003"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01599-09"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-025-10627-w"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00069-19"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof5040108"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis442"},{"key":"e_1_3_3_18_2","volume-title":"CLSI standard M38","author":"CLSI","year":"2017","unstructured":"CLSI. 2017. Reference method for broth dilution antifungal susceptibility testing of filamentous fungi. In CLSI standard M38, 3rd ed. Clinical and Laboratory Standards Institute.","edition":"3"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof9030306"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00241-25"},{"key":"e_1_3_3_21_2","unstructured":"Liofilchem S.r.l. 2015. MIC test strip technical sheet isavuconazole-MTS40 Rev.0. Italy Liofilchem S.r.l. Roseto degli Abruzzi"},{"key":"e_1_3_3_22_2","unstructured":"BioM\u00e9rieux SA. 2011. Etest technical guide No.10. Antifungal susceptibility testing of moulds. BioM\u00e9rieux SA: Marcy-l\u2019\u00c9toile France"},{"key":"e_1_3_3_23_2","volume-title":"CLSI supplement M57S","author":"CLSI","year":"2022","unstructured":"CLSI. 2022. Epidemiological cutoff values for antifungal susceptibility testing. In CLSI supplement M57S. 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