{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:29:55Z","timestamp":1787855395293,"version":"build-2784847793"},"reference-count":32,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The classic antibiotic treatment for Mediterranean spotted fever (MSF) is based on tetracyclines or chloramphenicol, but chloramphenicol's bone marrow toxicity makes tetracyclines the treatment of choice. However, it is convenient to have alternatives available for patients who are allergic to tetracyclines, pregnant women, and children &lt;8 years old. We conducted a randomized clinical trial to compare clarithromycin with doxycycline or josamycin in the treatment of MSF. Forty patients were evaluated (23 male; mean age, 39.87 years); 13 patients were aged &lt;14 years. Seventeen patients received clarithromycin, and 23 received doxycycline or josamycin. The interval between the onset of symptoms and the start of treatment was 4.04 \u00b1 1.70 days in the clarithromycin group versus 4.11 \u00b1 1.60 days in the doxycycline\/josamycin group (\n            <jats:italic>P<\/jats:italic>\n            = not significant [NS]). Time to the disappearance of fever after treatment was 2.67 \u00b1 1.55 days in the clarithromycin group versus 2.22 \u00b1 1.35 days in the doxycycline\/josamycin (\n            <jats:italic>P<\/jats:italic>\n            = NS). The symptoms had disappeared at 4.70 \u00b1 2.25 days in the clarithromycin group versus at 4.75 \u00b1 3.08 days in the doxycycline\/josamycin (\n            <jats:italic>P<\/jats:italic>\n            = NS). There were no adverse reactions to treatment or relapses in either group. In conclusion, clarithromycin is a good alternative to doxycycline or josamycin in the treatment of MSF.\n          <\/jats:p>","DOI":"10.1128\/aac.01814-15","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T03:23:15Z","timestamp":1451359395000},"page":"1642-1645","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Randomized Trial of Clarithromycin for Mediterranean Spotted Fever"],"prefix":"10.1128","volume":"60","author":[{"given":"Esperan\u00e7a","family":"Anton","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Corporaci\u00f3 Sanit\u00e0ria Parc Taul\u00ed, Sabadell, Barcelona, Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Medicine, Corporaci\u00f3 Sanit\u00e0ria Parc Taul\u00ed, Sabadell, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Traver\u00eda","sequence":"additional","affiliation":[{"name":"Department of Pediatric Medicine, Corporaci\u00f3 Sanit\u00e0ria Parc Taul\u00ed, Sabadell, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Navarro","sequence":"additional","affiliation":[{"name":"Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Department of Epidemiology, Corporaci\u00f3 Sanit\u00e0ria Parc Taul\u00ed, Sabadell, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernat","family":"Font","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Corporaci\u00f3 Sanit\u00e0ria Parc Taul\u00ed, Sabadell, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Sanfeliu","sequence":"additional","affiliation":[{"name":"Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Department of Microbiology, UDIAT-CD, Corporaci\u00f3 Sanit\u00e0ria Parc Taul\u00ed, Sabadell, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferran","family":"Segura","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Corporaci\u00f3 Sanit\u00e0ria Parc Taul\u00ed, Sabadell, Barcelona, Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/7.5.635"},{"key":"e_1_3_1_3_2","first-page":"121","article-title":"Fiebre botonosa mediterr\u00e1nea. Estudio de 246 casos","volume":"96","author":"Font Creus B","year":"1991","unstructured":"Font Creus B, Espejo Arenas E, Mu\u00f1oz Esp\u00edn T, Uriz Urzainqui S, Bella Cueto F, Segura Porta F. 1991. Fiebre botonosa mediterr\u00e1nea. Estudio de 246 casos. Med Clin (Barc) 96:121\u2013125.","journal-title":"Med Clin (Barc)"},{"key":"e_1_3_1_4_2","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s10096-002-0879-x","article-title":"Clinical and laboratory characteristics of 144 patients with Mediterranean spotted fever","volume":"22","author":"Ant\u00f3n E","year":"2003","unstructured":"Ant\u00f3n E, Font B, Mu\u00f1oz T, Sanfeliu I, Segura F. 2003. Clinical and laboratory characteristics of 144 patients with Mediterranean spotted fever. Eur J Clin Microbiol Infect Dis 22:126\u2013128.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"e_1_3_1_5_2","first-page":"394","article-title":"Malignant form of Mediterranean boutonneuse fever: importance of early treatment","volume":"8","author":"Lucio-Villegas ME","year":"1990","unstructured":"Lucio-Villegas ME, Lozano de Leon F, Iglesias MC, Gomez-Mateos JM, Lopez-Cortes L, Garcia-Bragado F. 1990. Malignant form of Mediterranean boutonneuse fever: importance of early treatment. Enferm Infecc Microbiol Clin 8:394.","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1586\/eri.12.139"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/155.5.1056"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.29.3.424"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.32.2.255"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.5.937"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.3.578"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/45.3.305"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.12.2633"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/321864"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/338068"},{"key":"e_1_3_1_16_2","first-page":"145","article-title":"Macrolides in the treatment of children with Mediterranean spotted fever","volume":"10","author":"Cascio A","year":"2002","unstructured":"Cascio A, Colomba C. 2002. Macrolides in the treatment of children with Mediterranean spotted fever. Infez Med 10:145\u2013150. (In Italian.)","journal-title":"Infez Med"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199611000-00022"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-6-60"},{"key":"e_1_3_1_19_2","first-page":"248","article-title":"Mediterranean spotted fever in paediatric and adult patients: two clinical aspects of the same disease","volume":"4","author":"Colomba C","year":"2011","unstructured":"Colomba C, Saporito L, Siracusa L, Giammanco G, Bonura S, Lucina T. 2011. Mediterranean spotted fever in paediatric and adult patients: two clinical aspects of the same disease. Infez Med 4:248\u2013253. (In Italian.)","journal-title":"Infez Med"},{"key":"e_1_3_1_20_2","first-page":"293","article-title":"Mediterranean spotted fever in childhood. Prospective study of 130 cases","volume":"28","author":"L\u00f3pez Par\u00e9s P","year":"1988","unstructured":"L\u00f3pez Par\u00e9s P, Munoz Espin T, Espejo Arenas E, Font Creus B, Segura Porta F, Martinez Vila I, Traver\u00eda Casanova J, Bella Cueto F. 1988. Mediterranean spotted fever in childhood. Prospective study of 130 cases. An Esp Pediatr 28:293\u2013296. (In Spanish.)","journal-title":"An Esp Pediatr"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/2009164259"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-0204-6_13"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00032-13"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.4065\/74.7.727"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199805000-00019"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.7.2739-2741.2004"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2006.00138.x"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(89)93567-6"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/164.2.433"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.33.6.987"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr218"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.61.10.1027"},{"key":"e_1_3_1_33_2","volume-title":"Abstr 6th Eur Congr Clin Microbiol Infect Dis","author":"Bella F","year":"1997","unstructured":"Bella F, Espejo E, Uritz S, Garc\u00eda JL, Mart\u00ednez A, Mauri M. 1997. Roxithromycin versus doxycycline for Mediterranean spotted fever (MSF), abstr P1374. Abstr 6th Eur Congr Clin Microbiol Infect Dis, Lausanne, Switzerland."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01814-15","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01814-15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:38:41Z","timestamp":1645475921000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01814-15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1128\/AAC.01814-15"],"URL":"https:\/\/doi.org\/10.1128\/aac.01814-15","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"2015-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}