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Whole-genome sequencing characterization using a combined short- and long-read sequencing approach showed that both isolates belonged to the same ST258 strain, had altered outer membrane porins (a truncated OmpK35 and an Asp137Thr138 duplication in the L3 loop of OmpK36), and carried novel pKpQIL plasmid derivatives (pIT-14159 and pIT-8788, respectively) harboring two copies of the Tn\n            <jats:italic>4401a<\/jats:italic>\n            KPC-3-encoding transposon.\n          <\/jats:p>","DOI":"10.1128\/aac.01816-19","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T13:22:37Z","timestamp":1579267357000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":59,"title":["Ceftazidime-Avibactam Resistance Associated with Increased\n            <i>bla<\/i>\n            <sub>KPC-3<\/sub>\n            Gene Copy Number Mediated by pKpQIL Plasmid Derivatives in Sequence Type 258\n            <i>Klebsiella pneumoniae<\/i>"],"prefix":"10.1128","volume":"64","author":[{"given":"Marco","family":"Coppi","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5863-5805","authenticated-orcid":false,"given":"Vincenzo","family":"Di Pilato","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Monaco","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pathology, Microbiology, and Virology, IRCCS-ISMETT, Palermo, 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