{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:57:12Z","timestamp":1790096232112,"version":"4.0.1"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100010318","name":"University of Manitoba","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010318","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>\n                    The\n                    <jats:italic>in vitro<\/jats:italic>\n                    activity of sulopenem was assessed against a collection from 2014 to 2016 of 539 urinary isolates of\n                    <jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>\n                    from Canadian patients by using CLSI-defined broth microdilution methodology. A concentration of sulopenem 0.03\u2009\u00b5g\/ml inhibited both 50% (MIC\n                    <jats:sub>50<\/jats:sub>\n                    ) and 90% (MIC\n                    <jats:sub>90<\/jats:sub>\n                    ) of isolates tested; sulopenem MICs ranged from 0.015 to 0.25\u2009\u00b5g\/ml.\n                  <\/jats:p>","DOI":"10.1128\/aac.01832-18","type":"journal-article","created":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T10:10:22Z","timestamp":1542622222000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["<i>In Vitro<\/i>\n                    Activity of Sulopenem, an Oral Penem, against Urinary Isolates of\n                    <i>Escherichia coli<\/i>"],"prefix":"10.1128","volume":"63","author":[{"given":"James A.","family":"Karlowsky","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather J.","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie R.","family":"Baxter","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Denisuik","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe R. S.","family":"Lagac\u00e9-Wiens","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Walkty","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sailaja","family":"Puttagunta","sequence":"additional","affiliation":[{"name":"Iterum Therapeutics, Old Saybrook, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Dunne","sequence":"additional","affiliation":[{"name":"Iterum Therapeutics, Old Saybrook, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George G.","family":"Zhanel","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq257"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-4399(02)80035-6"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2013.09.003"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/520138"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00066-11"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.06060-11"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2016.04.022"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2016.174"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2082693"},{"key":"e_1_3_2_11_2","volume-title":"Antimicrobial activity of sulopenem against Gram-positive and Gram-negative organisms from the United States and Europe (2013\u20132015), abstr Saturday-296","author":"Puttagunta S","year":"2017","unstructured":"Puttagunta S, Dunne M. 2017. 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