{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T23:42:16Z","timestamp":1779147736842,"version":"3.51.4"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The effects of the inoculum, pH, cation concentrations, and different lots of commercial media on the\n            <jats:italic>in vitro<\/jats:italic>\n            susceptibility of\n            <jats:italic>Clostridium difficile<\/jats:italic>\n            to fidaxomicin were examined. Of the factors evaluated, only pH alterations influenced the activity of fidaxomicin against\n            <jats:italic>C. difficile<\/jats:italic>\n            , noticeably reducing its activity at higher pH (\u22657.9).\n          <\/jats:p>","DOI":"10.1128\/aac.01842-09","type":"journal-article","created":{"date-parts":[[2010,3,23]],"date-time":"2010-03-23T01:42:20Z","timestamp":1269308540000},"page":"2674-2676","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Effects of Inoculum, pH, and Cations on the\n            <i>In Vitro<\/i>\n            Activity of Fidaxomicin (OPT-80, PAR-101) against\n            <i>Clostridium difficile<\/i>"],"prefix":"10.1128","volume":"54","author":[{"given":"F.","family":"Babakhani","sequence":"first","affiliation":[{"name":"Departments of Biology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Seddon","sequence":"additional","affiliation":[{"name":"Departments of Biology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Robert","sequence":"additional","affiliation":[{"name":"Departments of Biology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.-K.","family":"Shue","sequence":"additional","affiliation":[{"name":"Clinical Development, Optimer Pharmaceuticals, Inc., San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Sears","sequence":"additional","affiliation":[{"name":"Departments of Biology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.6.2280-2282.2004"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/383045"},{"key":"e_1_3_1_4_2","first-page":"207","volume":"66","year":"2008","unstructured":"Bauer, M. 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