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The tolerability of 50 (double the standard dose) and 70\u2009mg\/kg total chloroquine doses were assessed in this study. Fifteen 4- to 8-year-old children with uncomplicated malaria were given 10\u2009mg\/kg of chloroquine twice daily for 2 days and 5\u2009mg\/kg twice daily on the third day.\n          <\/jats:p>","DOI":"10.1128\/aac.01846-19","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T13:00:03Z","timestamp":1578056403000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["High-Dose Chloroquine for Uncomplicated Plasmodium falciparum Malaria Is Well Tolerated and Causes Similar QT Interval Prolongation as Standard-Dose Chloroquine in Children"],"prefix":"10.1128","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5508-9327","authenticated-orcid":false,"given":"Johan","family":"Ursing","sequence":"first","affiliation":[{"name":"Projecto de Sa\u00fade de Bandim, Indepth Network, Bissau, Guinea-Bissau"},{"name":"Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden"},{"name":"Department of Infectious Diseases, Danderyd Hospital, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Rombo","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research, S\u00f6rmland County Council, Eskilstuna, Sweden"},{"name":"Uppsala University, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Staffan","family":"Eksborg","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Childhood Cancer Research Unit, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Larson","sequence":"additional","affiliation":[{"name":"Projecto de Sa\u00fade de Bandim, Indepth Network, Bissau, Guinea-Bissau"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Bruvoll","sequence":"additional","affiliation":[{"name":"Projecto de Sa\u00fade de Bandim, Indepth Network, Bissau, Guinea-Bissau"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4566-4030","authenticated-orcid":false,"given":"Joel","family":"Tarning","sequence":"additional","affiliation":[{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"},{"name":"Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amabelia","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Projecto de Sa\u00fade de Bandim, Indepth Network, Bissau, Guinea-Bissau"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poul-Erik","family":"Kofoed","sequence":"additional","affiliation":[{"name":"Projecto de Sa\u00fade de Bandim, Indepth Network, Bissau, Guinea-Bissau"},{"name":"Department of Paediatrics, Kolding Hospital, Frederiksberg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"Guidelines for the treatment of malaria","author":"World Health Organization","year":"2015","unstructured":"World Health Organization. 2015. 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