{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T21:55:54Z","timestamp":1789854954744,"version":"4.0.1"},"reference-count":31,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Fondo de Investigaci\u00f3n Sanitaria","award":["MSI15\/00115"],"award-info":[{"award-number":["MSI15\/00115"]}]},{"name":"Fondo de Investigaci\u00f3n Sanitaria","award":["PI16\/01012"],"award-info":[{"award-number":["PI16\/01012"]}]},{"name":"Fondo de Investigaci\u00f3n Sanitaria","award":["PI14\/00740"],"award-info":[{"award-number":["PI14\/00740"]}]},{"DOI":"10.13039\/501100008530","name":"FEDER","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100014365","name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n","doi-asserted-by":"crossref","award":["II-Predoc-2016-IISGM"],"award-info":[{"award-number":["II-Predoc-2016-IISGM"]}],"id":[{"id":"10.13039\/501100014365","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>\n            The high rates of antifungal resistance in\n            <jats:named-content content-type=\"genus-species\">Candida glabrata<\/jats:named-content>\n            may be facilitated by the presence of alterations in the\n            <jats:italic>MSH2<\/jats:italic>\n            gene. We aimed to study the sequence of the\n            <jats:italic>MSH2<\/jats:italic>\n            gene in 124 invasive\n            <jats:named-content content-type=\"genus-species\">C. glabrata<\/jats:named-content>\n            isolates causing incident episodes of candidemia (\n            <jats:italic>n<\/jats:italic>\n            = 81), subsequent candidemia episodes (\n            <jats:italic>n<\/jats:italic>\n            = 9), endocarditis (\n            <jats:italic>n<\/jats:italic>\n            = 2), and\n            <jats:italic>in vitro<\/jats:italic>\n            -generated echinocandin-resistant isolates (\n            <jats:italic>n<\/jats:italic>\n            = 32) and assessed its relationship with genotypes, acquisition of antifungal resistance\n            <jats:italic>in vivo<\/jats:italic>\n            and\n            <jats:italic>in vitro<\/jats:italic>\n            , and patient prognosis.\n          <\/jats:p>","DOI":"10.1128\/aac.01876-18","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T11:11:16Z","timestamp":1545304276000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["<i>MSH2<\/i>\n            Gene Point Mutations Are Not Antifungal Resistance Markers in\n            <i>Candida glabrata<\/i>"],"prefix":"10.1128","volume":"63","author":[{"given":"Mar\u00eda \u00c1ngeles","family":"Bordallo-Cardona","sequence":"first","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Agnelli","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"G\u00f3mez-Nu\u00f1ez","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"S\u00e1nchez-Carrillo","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Bouza","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Madrid, Spain"},{"name":"CIBER Enfermedades Respiratorias (CIBERES) (CB06\/06\/0058), Madrid, Spain"},{"name":"Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Madrid, Spain"},{"name":"CIBER Enfermedades Respiratorias (CIBERES) (CB06\/06\/0058), Madrid, Spain"},{"name":"Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Escribano","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7901-8355","authenticated-orcid":false,"given":"Jes\u00fas","family":"Guinea","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Madrid, Spain"},{"name":"CIBER Enfermedades Respiratorias (CIBERES) (CB06\/06\/0058), Madrid, Spain"},{"name":"Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02155-13"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.9.3640-3645.2005"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/504810"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ933"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.06112-11"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofv163"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit136"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01998-13"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12472"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01542-16"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myx124"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01982-17"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-014-0286-5"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00299-07"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11128"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.02038"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00195-18"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00595-17"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00153-18"},{"key":"e_1_3_2_21_2","volume-title":"28th European Congress of Clinical Microbiology and Infectious Diseases","author":"Deshpande LMPM","year":"2018","unstructured":"Deshpande LMPM, Castanheira M. 2018. Prevalence of MSH2 mutator genotype in echinocandin-resistant Candida glabrata from a 3-year global surveillance program. 28th European Congress of Clinical Microbiology and Infectious Diseases, 21 to 24 April 2018, Madrid, Spain."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.11.027"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myx030"},{"key":"e_1_3_2_24_2","volume-title":"28th European Congress of Clinical Microbiology and Infectious Diseases","author":"Byun SA","year":"2018","unstructured":"Byun SA, Won EJ, Choi MJ, Kwon YJ, Shin JH, Kim SH, Lee WG, Kim MN, Lee K, Lee HS, Lee J. 2018. Comparison of the clinical characteristics of Candida glabrata bloodstream isolates with different genotypes as determined by multilocus sequence typing. 28th European Congress of Clinical Microbiology and Infectious Diseases, 21 to 24 April 2018, Madrid, Spain."},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01250-15"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof3020024"},{"key":"e_1_3_2_27_2","first-page":"315","volume-title":"PCR protocols: a guide to methods and applications","author":"White T","year":"1990","unstructured":"White T, Bruns T, Lee S, Taylor J. 1990. Amplification and direct sequencing of fungal ribosomal RNA genes for phylogenetics, p 315\u2013322. In Innis MA, Gelfand DH, Sninsky JJ, White TJ (ed), PCR protocols: a guide to methods and applications. Academic Press, San Diego, CA."},{"key":"e_1_3_2_28_2","unstructured":"Arendrup MC Meletiadis J Mouton JW Lagrou K Hamal P Guinea J. 2017. EUCAST Definitive document E.DEF 7.3.1. Method for the determination of broth dilution minimum Inhibitory concentrations of antifungal agents for yeasts. http:\/\/www.eucast.org\/fileadmin\/src\/media\/PDFs\/EUCAST_files\/AFST\/Files\/EUCAST_E_Def_7_3_1_Yeast_testing__definitive.pdf."},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.9.4574-4579.2005"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-011-1280-4"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01603-07"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.12.5709-5717.2003"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01876-18","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01876-18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:21:20Z","timestamp":1645478480000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01876-18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1128\/AAC.01876-18"],"URL":"https:\/\/doi.org\/10.1128\/aac.01876-18","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"2018-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01876-18"}}