{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:33:04Z","timestamp":1785407584668,"version":"3.56.0"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Menarini Spain"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2026,6,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Chromosomal tandem duplications are scarcely reported in\n                      <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                      . We describe a chromosomal\n                      <jats:italic toggle=\"yes\">fosA6<\/jats:italic>\n                      tandem multicopy fragment present at varying copy number in five consecutive\n                      <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                      carbapenemase-producing\n                      <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                      isolates recovered from a single patient over 27 months. Fosfomycin minimum inhibitory concentrations increased with copy number; however, fosA6 expression did not scale proportionally with copy number. No other fosfomycin resistance mechanism was identified. This highlights the clinical relevance of chromosomal AMR gene amplifications.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.01877-25","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T10:00:21Z","timestamp":1776679221000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Description of a chromosomal\n                    <i>fosA6<\/i>\n                    tandem multicopy fragment and its\n                    <i>in vivo<\/i>\n                    evolution in consecutive KPC-producing\n                    <i>Klebsiella pneumoniae<\/i>\n                    clinical isolates"],"prefix":"10.1128","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0854-9703","authenticated-orcid":true,"given":"Mar\u00eda 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