{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:12:36Z","timestamp":1793419956008,"version":"4.5.0"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100002632","name":"Hallym University","doi-asserted-by":"publisher","award":["MHC-202405-002"],"award-info":[{"award-number":["MHC-202405-002"]}],"id":[{"id":"10.13039\/501100002632","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003653","name":"Korea National Institute of Health","doi-asserted-by":"publisher","award":["2024-ER2208-00"],"award-info":[{"award-number":["2024-ER2208-00"]}],"id":[{"id":"10.13039\/501100003653","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2025,6,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Differences exist between Infectious Diseases Society of America guidance and European Society of Clinical Microbiology and Infectious Diseases guidelines on treating pneumonia caused by carbapenem-resistant\n                      <jats:italic toggle=\"yes\">Acinetobacter baumannii<\/jats:italic>\n                      (CRAB). This study compared the outcomes of colistin-based and high-dose ampicillin\/sulbactam-based combination therapies in patients with CRAB nosocomial pneumonia. A retrospective cohort study was conducted at a university-affiliated hospital in South Korea. Patients received either a colistin-based regimen with a loading dose followed by a maintenance dose (June 2021\u2013May 2022) or a high-dose ampicillin\/sulbactam-based regimen with sulbactam 9 g\/day (October 2022\u2013September 2023). The primary outcome was 28-day all-cause mortality; secondary outcomes included 14-day\/28-day clinical success rates and 14-day\/28-day kidney injury based on the Risk, Injury, Failure, Loss, End-stage renal disease score. Logistic and Poisson regression analyses were used to compare outcomes between groups. Among 179 patients enrolled in the study, 84 received the colistin-based regimen and 95 received the high-dose ampicillin\/sulbactam-based regimen. The ampicillin\/sulbactam group showed significantly lower 28-day mortality (20% vs. 61%; adjusted relative risk [aRR] = 0.16, 95% CI 0.08\u20130.32). Clinical success rates were higher in the ampicillin\/sulbactam group at both 14 days (39% vs. 23%; aRR = 2.19, 95% CI 1.10\u20134.37) and 28 days (55% vs. 32%; aRR = 2.71, 95% CI 1.14\u20135.20). Additionally, 28-day kidney injury was lower in the ampicillin\/sulbactam group (0.63 \u00b1 1.16 vs. 1.06 \u00b1 1.35; aRR = 0.56, 95% CI 0.40\u20130.79). High-dose ampicillin\/sulbactam-based combination therapy demonstrates superior outcomes over colistin-based combination therapy for CRAB nosocomial pneumonia, including lower mortality, higher clinical success rates, and reduced kidney injury.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.01880-24","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T09:02:34Z","timestamp":1745398954000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Comparative effectiveness and safety of colistin-based versus high-dose ampicillin\/sulbactam-based combination therapy for nosocomial pneumonia caused by carbapenem-resistant\n                    <i>Acinetobacter baumannii<\/i>"],"prefix":"10.1128","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8143-8501","authenticated-orcid":false,"given":"Jaehoon","family":"Lee","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03sbhge02","id-type":"ROR","asserted-by":"publisher"}],"name":"Hallym University College of Medicine","place":["Chuncheon, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4509-2936","authenticated-orcid":false,"given":"Imchang","family":"Lee","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03sbhge02","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Life Science, Multidisciplinary Genome Institute, Hallym University","place":["Chuncheon, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9106-5528","authenticated-orcid":false,"given":"Ki-Byung","family":"Lee","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03sbhge02","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine","place":["Chuncheon, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1797-3426","authenticated-orcid":true,"given":"Seung Soon","family":"Lee","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03sbhge02","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Infectious Diseases, Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine","place":["Chuncheon, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.15620\/cdc:82532"},{"key":"e_1_3_4_3_2","volume-title":"WHO bacterial priority pathogens list, 2024","year":"2024","unstructured":"World Health Organization (WHO). 2024. In WHO bacterial priority pathogens list, 2024. WHO Antimicrobial Resistance Division, Geneva, Switzerland."},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2018.38.2.179"},{"key":"e_1_3_4_5_2","first-page":"2007","article-title":"Trends of antimicrobial resistance rates of major clinical pathogens isolated from general hospitals in Korea in 2016-2019: results from Kor-GLASS","volume":"14","author":"Kim JW","year":"2021","unstructured":"Kim JW, Bae SM, Lee SY, Yoo JS, Choo SY. 2021. Trends of antimicrobial resistance rates of major clinical pathogens isolated from general hospitals in Korea in 2016-2019: results from Kor-GLASS. 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