{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:23:46Z","timestamp":1790429026035,"version":"4.1.0"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["32003B_153377"],"award-info":[{"award-number":["32003B_153377"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["CCM 2014"],"award-info":[{"award-number":["CCM 2014"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A carbapenem-resistant sequence type 512 (ST512)\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Klebsiella pneumoniae<\/jats:named-content>\n                    carbapenemase 3 (KPC-3)-producing\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">K. pneumoniae<\/jats:named-content>\n                    strain showing a novel variant plasmid content was isolated in Palermo, Italy, in 2014. ST512 is a worldwide successful clone associated with the spread of\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>KPC<\/jats:sub>\n                    genes located on the IncFIIk pKpQIL plasmid. In our ST512 strain, the\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>KPC-3<\/jats:sub>\n                    gene was unusually located on an IncX3 plasmid, whose complete sequence was determined. Two copies of\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>KPC-3<\/jats:sub>\n                    ::Tn\n                    <jats:italic>4401a<\/jats:italic>\n                    caused by intramolecular transposition events were detected in the plasmid.\n                  <\/jats:p>","DOI":"10.1128\/aac.01886-15","type":"journal-article","created":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T20:35:21Z","timestamp":1446496521000},"page":"646-649","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":37,"title":["Double Copies of\n                    <i>bla<\/i>\n                    <sub>KPC-3<\/sub>\n                    ::Tn\n                    <i>4401a<\/i>\n                    on an IncX3 Plasmid in Klebsiella pneumoniae Successful Clone ST512 from Italy"],"prefix":"10.1128","volume":"60","author":[{"given":"Daniela","family":"Fortini","sequence":"first","affiliation":[{"name":"Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Villa","sequence":"additional","affiliation":[{"name":"Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Feudi","sequence":"additional","affiliation":[{"name":"Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Pires","sequence":"additional","affiliation":[{"name":"Institute for Infectious Diseases, University of Bern, Bern, Switzerland"},{"name":"Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celestino","family":"Bonura","sequence":"additional","affiliation":[{"name":"Department of Sciences for Health Promotion and Mother-Child Care G. D'Alessandro, University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Mammina","sequence":"additional","affiliation":[{"name":"Department of Sciences for Health Promotion and Mother-Child Care G. D'Alessandro, University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3186-5421","authenticated-orcid":false,"given":"Andrea","family":"Endimiani","sequence":"additional","affiliation":[{"name":"Institute for Infectious Diseases, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Carattoli","sequence":"additional","affiliation":[{"name":"Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanit\u00e0, Rome, Italy"},{"name":"Institute for Infectious Diseases, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03570.x"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01019-15"},{"key":"e_1_3_1_4_2","doi-asserted-by":"crossref","unstructured":"Giani T Pini B Arena F Conte V Bracco S Migliavacca R AMCLI-CRE Survey Participants Pantosti A Pagani L Luzzaro F Rossolini GM. 2013. Epidemic diffusion of KPC carbapenemase-producing Klebsiella pneumoniae in Italy: results of the first countrywide survey 15 May to 30 June 2011. Euro Surveill 18:pii=20489. http:\/\/www.eurosurveillance.org\/ViewArticle.aspx?ArticleId=20489.","DOI":"10.2807\/ese.18.22.20489-en"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132936"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2010.12.002"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.6.2153-2162.2002"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn470"},{"key":"e_1_3_1_9_2","first-page":"553","volume-title":"Diagnostic molecular microbiology: principles and applications","author":"Mabilat C","year":"1995","unstructured":"Mabilat C, Goussard S. 1995. PCR detection and identification of genes for extended-spectrum beta-lactamases, p 553\u2013559. In Persing DH, Smith TF, Tenover FC, White TJ (ed), Diagnostic molecular microbiology: principles and applications. American Society for Microbiology, Washington, DC."},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plasmid.2012.03.001"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01451-07"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05308-11"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01712-12"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.00272-15"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00008-10"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05118-11"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1609.091389"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01355-08"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12070"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00175-10"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01886-15","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01886-15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:36:13Z","timestamp":1645457773000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01886-15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1128\/AAC.01886-15"],"URL":"https:\/\/doi.org\/10.1128\/aac.01886-15","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2015-08-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}