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In this study, we analyzed 86\n                      <jats:italic toggle=\"yes\">S. algae<\/jats:italic>\n                      isolates from Spain (19 clinical and 67 environmental) and integrated them with 178 publicly available genomes to explore antimicrobial susceptibility patterns and genomic diversity. Penicillins and fosfomycin consistently showed poor activity, whereas piperacillin\/tazobactam, third- and fourth-generation cephalosporins, aminoglycosides, ciprofloxacin, trimethoprim\u2013sulfamethoxazole and several novel \u03b2-lactam\u2013inhibitor combinations exhibited low MIC distributions. Recently introduced agents, including ceftazidime\/avibactam, ceftolozane\/tazobactam, and cefiderocol, also demonstrated strong\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      activity. Carbapenems displayed an unusual intraclass pattern, with imipenem showing markedly higher MICs than meropenem and ertapenem. When interpreted using CLSI\u2019s \u201cOther Non-Enterobacterales\u201d criteria, clinical and environmental isolates exhibited largely overlapping susceptibility profiles, highlighting the potential role of environmental strains as reservoirs of resistance-related traits. Genomic profiling revealed a conserved intrinsic resistome (OXA-type \u03b2-lactamases,\n                      <jats:italic toggle=\"yes\">qnrA<\/jats:italic>\n                      variants,\n                      <jats:italic toggle=\"yes\">ugd<\/jats:italic>\n                      , and efflux regulators) together with horizontally acquired determinants. A 29 kb genomic island carrying multiple resistance genes was identified in a clinical isolate, with homologous structures detected in\n                      <jats:italic toggle=\"yes\">Vibrio<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Proteus<\/jats:italic>\n                      , suggesting interspecies transfer. Furthermore, plasmids harboring class 1 integrons (mobile integrons) were widespread, shared with Enterobacterales and\n                      <jats:italic toggle=\"yes\">Vibrionaceae<\/jats:italic>\n                      across clinical and environmental settings. Overall, these findings highlight\n                      <jats:italic toggle=\"yes\">S. algae<\/jats:italic>\n                      as both a clinically relevant pathogen and a reservoir of mobile AMR determinants and underscore the urgent need for species-specific antimicrobial susceptibility interpretive criteria to improve clinical decision-making for this emerging pathogen.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.01891-25","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:55:06Z","timestamp":1776264906000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Bridging clinical and environmental reservoirs: antimicrobial resistance in the emerging pathogen\n                    <i>Shewanella algae<\/i>"],"prefix":"10.1128","volume":"70","author":[{"given":"Celia","family":"Garc\u00eda-Rivera","sequence":"first","affiliation":[{"name":"Microbiology Department, Alicante University General Hospital, Alicante Institute of Sanitary and Biomedical Research (ISABIAL)","place":["Alicante, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan J.","family":"Roda-Garcia","sequence":"additional","affiliation":[{"name":"Microbial Genomics and Evolution Group, Divisi\u00f3n de Microbiolog\u00eda, Universidad Miguel Hern\u00e1ndez","place":["Alicante, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Microbiology Department, Alicante University General Hospital, Alicante Institute of Sanitary and Biomedical Research (ISABIAL)","place":["Alicante, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Molina-Pardines","sequence":"additional","affiliation":[{"name":"Microbial Genomics and Evolution Group, Divisi\u00f3n de Microbiolog\u00eda, Universidad Miguel Hern\u00e1ndez","place":["Alicante, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iryna","family":"Tyshkovska","sequence":"additional","affiliation":[{"name":"Microbiology Department, Alicante University General Hospital, Alicante Institute of Sanitary and Biomedical Research (ISABIAL)","place":["Alicante, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2113-9269","authenticated-orcid":true,"given":"Jose M.","family":"Haro-Moreno","sequence":"additional","affiliation":[{"name":"Microbial Genomics and Evolution Group, Divisi\u00f3n de Microbiolog\u00eda, Universidad Miguel Hern\u00e1ndez","place":["Alicante, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Mart\u00ednez-Murcia","sequence":"additional","affiliation":[{"name":"Microbial Genomics and Evolution Group, Divisi\u00f3n de Microbiolog\u00eda, Universidad Miguel Hern\u00e1ndez","place":["Alicante, Spain"]},{"name":"Genetic PCR Solutions","place":["Orihuela, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1979-0949","authenticated-orcid":true,"given":"Maria Paz","family":"Ventero","sequence":"additional","affiliation":[{"name":"Microbiology Department, Alicante University General Hospital, Alicante Institute of Sanitary and Biomedical Research (ISABIAL)","place":["Alicante, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3996-6780","authenticated-orcid":true,"given":"Mario","family":"L\u00f3pez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Microbial Genomics and 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