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These long-acting reservoir implants were able to deliver antiretroviral drug for over 90\u2009days\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    . We evaluated the implants for implantation site histopathology and pharmacokinetics in plasma and tissues for up to 12\u2009weeks in New Zealand White rabbit and rhesus macaque models.\n                  <\/jats:p>","DOI":"10.1128\/aac.01893-19","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T05:45:57Z","timestamp":1576647957000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":57,"title":["A Subcutaneous Implant of Tenofovir Alafenamide Fumarate Causes Local Inflammation and Tissue Necrosis in Rabbits and Macaques"],"prefix":"10.1128","volume":"64","author":[{"given":"Jonathan T.","family":"Su","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA"},{"name":"Department of Physics and Engineering, Elon University, Elon, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solange M.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa Bryndza","family":"Tfaily","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Northwestern University, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Veazey","sequence":"additional","affiliation":[{"name":"Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Marzinke","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Watrous","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakmini","family":"Widanapathirana","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Pearson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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