{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:26:15Z","timestamp":1790439975369,"version":"4.1.0"},"reference-count":12,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19fk0108150"],"award-info":[{"award-number":["JP19fk0108150"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,11,17]]},"abstract":"<jats:p>Favipiravir is an oral broad-spectrum inhibitor of viral RNA-dependent RNA polymerase that is approved for treatment of influenza in Japan. We conducted a prospective, randomized, open-label, multicenter trial of favipiravir for the treatment of COVID-19 at 25 hospitals across Japan. Eligible patients were adolescents and adults admitted with COVID-19 who were asymptomatic or mildly ill and had an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. Patients were randomly assigned at a 1:1 ratio to early or late favipiravir therapy (in the latter case, the same regimen starting on day 6 instead of day 1).<\/jats:p>","DOI":"10.1128\/aac.01897-20","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T13:47:51Z","timestamp":1600782471000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":183,"title":["A Prospective, Randomized, Open-Label Trial of Early versus Late Favipiravir Therapy in Hospitalized Patients with COVID-19"],"prefix":"10.1128","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9620-2525","authenticated-orcid":false,"given":"Yohei","family":"Doi","sequence":"first","affiliation":[{"name":"Departments of Microbiology and Infectious Diseases, Fujita Health University School of Medicine, Toyoake, Aichi, Japan"},{"name":"Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Hibino","sequence":"additional","affiliation":[{"name":"Department of Emergency and General Internal Medicine, Fujita Health University School of Medicine, Toyoake, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Hase","sequence":"additional","affiliation":[{"name":"Departments of Microbiology and Infectious Diseases, Fujita Health University School of Medicine, Toyoake, Aichi, Japan"},{"name":"Department of Infectious Diseases, Japanese Red Cross Narita Hospital, Narita, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Sagamihara Kyodo Hospital, Sagamihara, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Kasamatsu","sequence":"additional","affiliation":[{"name":"Infection Control and Clinical Laboratory, Kyoto Prefectural University of Medicine, Kyoto, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Hirose","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Fujita Health University Bantane Hospital, Nagoya, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7368-3004","authenticated-orcid":false,"given":"Yoshikazu","family":"Mutoh","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Tosei General Hospital, Seto, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Homma","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Ehime Prefectural Central Hospital, Matsuyama, Ehime, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Terada","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Saiseikai Niigata Hospital, Niigata, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases, Nara Medical University, Kashihara, Nara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiro","family":"Kashizaki","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Isehara Kyodo Hospital, Isehara, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Koba","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Komatsu Municipal Hospital, Komatsu, Ishikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, NTT East Sapporo Hospital, Sapporo, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Yokota","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Tokyo Metropolitan Health and Medical Corporation Ebara Hospital, Ohta, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Kato","sequence":"additional","affiliation":[{"name":"Infection Prevention and Control Department, Yokohama City University Hospital, Yokohama, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Chest Surgery, Shimonoseki City Hospital, Shimonoseki, Yamaguchi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Kita","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, National Hospital Organization Kanazawa Medical Center, Kanazawa, Ishikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, International University of Health and Welfare Narita Hospital, Narita, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Kamio","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Shonan Kamakura General Hospital, Kamakura, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Kodama","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, Fukuoka Tokushukai Hospital, Kasuga, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiro","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Kitakyushu Municipal Medical Center, Kitakyushu, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, Eiju General Hospital, Taito, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Shinoda","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Shinagawa, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Nakatsumi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Ishikawa Prefectural Central Hospital, Kanazawa, Ishikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Horiguchi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Fujita Health University School of Medicine, Toyoake, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsunaga","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Emergency and General Internal Medicine, Fujita Health University School of Medicine, Toyoake, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akifumi","family":"Matsuyama","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine and Stem Cell Biology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumi","family":"Banno","sequence":"additional","affiliation":[{"name":"Center for Clinical Trial and Research Support, Fujita Health University School of Medicine, Toyoake, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takenao","family":"Koseki","sequence":"additional","affiliation":[{"name":"Center for Clinical Trial and Research Support, Fujita Health University School of Medicine, Toyoake, Aichi, Japan"},{"name":"Department of Clinical Pharmacy, Fujita Health University School of Medicine, Toyoake, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Teramachi","sequence":"additional","affiliation":[{"name":"Center for Clinical Trial and Research Support, Fujita Health University School of Medicine, Toyoake, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Miyata","sequence":"additional","affiliation":[{"name":"Center for Clinical Trial and Research Support, Fujita Health University School of Medicine, Toyoake, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Tajima","sequence":"additional","affiliation":[{"name":"Department of Virology I, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Maeki","sequence":"additional","affiliation":[{"name":"Department of Virology I, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Virology I, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Virology I, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Kweng","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Virology I, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5458-7298","authenticated-orcid":false,"given":"Masayuki","family":"Saijo","sequence":"additional","affiliation":[{"name":"Department of Virology I, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Osaka City University Graduate School of Medicine, Osaka, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisako","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Osaka City University Graduate School of Medicine, Osaka, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daijiro","family":"Kabata","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Osaka City University Graduate School of Medicine, Osaka, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Shintani","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Osaka City University Graduate School of Medicine, Osaka, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Yuzawa","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Fujita Health University School of Medicine, Toyoake, Aichi, Japan"},{"name":"Center for Clinical Trial and Research Support, Fujita Health University School of Medicine, Toyoake, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.2648"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2018.03.003"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.09.015"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107512"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eng.2020.03.007"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1176"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2020.07.003"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.JJID.2020.108"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.0c00464"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.JJID.2020.061"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.251.87"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-198212000-00014"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01897-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01897-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:39:57Z","timestamp":1645479597000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01897-20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,17]]},"references-count":12,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,11,17]]}},"alternative-id":["10.1128\/AAC.01897-20"],"URL":"https:\/\/doi.org\/10.1128\/aac.01897-20","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,17]]},"assertion":[{"value":"2020-09-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01897-20"}}