{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:57:29Z","timestamp":1791284249313,"version":"4.1.0"},"reference-count":65,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Schistosomiasis is a chronic and debilitating disease caused by a trematode of the genus\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Schistosoma<\/jats:named-content>\n                    and affects over 207 million people. Chemotherapy is the only immediate recourse for minimizing the prevalence of this disease and involves predominately the administration of a single drug, praziquantel (PZQ). Although PZQ has proven efficacy, there is a recognized need to develop new drugs as schistosomicides since studies have shown that repeated use of this drug in areas of endemicity may cause a temporary reduction in susceptibility in isolates of\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Schistosoma mansoni<\/jats:named-content>\n                    . Hydrazones, thiosemicarbazones, phthalimides, and thiazoles are thus regarded as privileged structures used for a broad spectrum of activities and are potential candidates for sources of new drug prototypes. The present study determined the\n                    <jats:italic>in vitro<\/jats:italic>\n                    schistosomicidal activity of 10 molecules containing these structures. During the assays, parameters such motility and mortality, oviposition, morphological changes in the tegument, cytotoxicity, and immunomodulatory activity caused by these compounds were evaluated. The results showed that compounds formed of thiazole and phthalimide led to higher mortality of worms, with a significant decline in motility, inhibition of pairing and oviposition, and a mortality rate of 100% starting from 144 h of exposure. These compounds also stimulated the production of nitric oxide and tumor necrosis factor alpha (TNF-\u03b1), thereby demonstrating the presence of immunomodulatory activity. The phthalyl thiazole LpQM-45 caused significant ultrastructural alterations, with destruction of the tegument in both male and female worms. According to the present study, phthalyl thiazole compounds possess antischistosomal activities and should form the basis for future experimental and clinical trials.\n                  <\/jats:p>","DOI":"10.1128\/aac.01900-13","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T23:36:25Z","timestamp":1383003385000},"page":"352-363","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":61,"title":["Evaluation of the Anti-Schistosoma mansoni Activity of Thiosemicarbazones and Thiazoles"],"prefix":"10.1128","volume":"58","author":[{"given":"Edna de Farias","family":"Santiago","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Federal University of Pernambuco, Recife, PE, Brazil"},{"name":"Laboratory of Immunopathology, CPqAM\/FIOCRUZ, Recife, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheilla Andrade","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology, CPqAM\/FIOCRUZ, Recife, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gev\u00e2nio Bezerra","family":"de Oliveira Filho","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Federal University of Pernambuco, Recife, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo Rodrigo Magalhaes","family":"Moreira","sequence":"additional","affiliation":[{"name":"Gon\u00e7alo Moniz Research Center\/FIOCRUZ, Salvador, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Andr\u00e9 Teixeira","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Federal University of Pernambuco, Recife, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anek\u00e9cia Lauro","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology, CPqAM\/FIOCRUZ, Recife, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9ia Ferreira","family":"de Barros","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology, CPqAM\/FIOCRUZ, Recife, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Caroline","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics, CPqAM\/FIOCRUZ, Recife, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Andr\u00e9 Ramos","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics, CPqAM\/FIOCRUZ, Recife, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria R\u00eago Alves","family":"Pereira","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics, CPqAM\/FIOCRUZ, Recife, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Gazzoni Ara\u00fajo","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology Keizo Asami\/Laboratory of Cell Biology and Molecular, CPqAM\/FIOCRUZ, Recife, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio Andr\u00e9","family":"Brayner","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology Keizo Asami\/Laboratory of Cell Biology and Molecular, CPqAM\/FIOCRUZ, Recife, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Carlos","family":"Alves","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology Keizo Asami\/Laboratory of Cell Biology and Molecular, CPqAM\/FIOCRUZ, Recife, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almir Gon\u00e7alves","family":"Wanderley","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cristina Lima","family":"Leite","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Federal University of Pernambuco, Recife, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-89102004000100010"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000350.g001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2010.08.021"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2012.06.005"},{"key":"e_1_3_2_6_2","volume-title":"Schistosomiasis: epidemiological situation","author":"WHO","year":"2012","unstructured":"WHO. 2012. 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