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Resistance was associated with amino acid substitutions in ampC and OXA \u03b2-lactamases, or mutations in regulatory genes conferring hyper-production of AmpC and MexAB-OprM efflux pumps. Cross-resistance was common between ceftazidime-avibactam and ceftolozane-tazobactam, less common for imipenem-relebactam and cefepime-zidebactam, and lowest for cefiderocol. These findings have important implications for sequential treatment of\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      infections.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.01910-25","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T14:29:52Z","timestamp":1775485792000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Ceftazidime-avibactam resistance evolution in\n                    <i>Pseudomonas aeruginosa<\/i>\n                    and implications for cross-resistance to other novel \u03b2-lactams"],"prefix":"10.1128","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8148-8835","authenticated-orcid":false,"given":"Ava 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