{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:15:45Z","timestamp":1791400545243,"version":"4.3.3"},"reference-count":35,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Sant\u00e9 Publique France"},{"DOI":"10.13039\/501100015722","name":"Centre hospitalier universitaire de Clermont-Ferrand","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100015722","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006488","name":"Institut National de la Recherche Agronomique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006488","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004793","name":"Ministere de l'Education Nationale, de l'Enseignement Sup\u00e9rieur et de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The objective of this study was to perform an inventory of the extended-spectrum-\u03b2-lactamase (ESBL)-producing\n            <jats:named-content content-type=\"genus-species\">Enterobacteriaceae<\/jats:named-content>\n            isolates responsible for infections in French hospitals and to assess the mechanisms associated with ESBL diffusion. A total of 200 nonredundant ESBL-producing\n            <jats:named-content content-type=\"genus-species\">Enterobacteriaceae<\/jats:named-content>\n            strains isolated from clinical samples were collected during a multicenter study performed in 18 representative French hospitals. Antibiotic resistance genes were identified by PCR and sequencing experiments. The clonal relatedness between isolates was investigated by the use of the DiversiLab system. ESBL-encoding plasmids were compared by PCR-based replicon typing and plasmid multilocus sequence typing. CTX-M-15, CTX-M-1, CTX-M-14, and SHV-12 were the most prevalent ESBLs (8% to 46.5%). The three CTX-M-type EBSLs were significantly observed in\n            <jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>\n            (37.1%, 24.2%, and 21.8%, respectively), and CTX-M-15 was the predominant ESBL in\n            <jats:named-content content-type=\"genus-species\">Klebsiella pneumoniae<\/jats:named-content>\n            (81.1%). SHV-12 was associated with ESBL-encoding\n            <jats:named-content content-type=\"genus-species\">Enterobacter cloacae<\/jats:named-content>\n            strains (37.9%).\n            <jats:italic>qnrB<\/jats:italic>\n            ,\n            <jats:italic>aac(6<\/jats:italic>\n            \u2032\n            <jats:italic>)-Ib-cr<\/jats:italic>\n            , and\n            <jats:italic>aac(3)-II<\/jats:italic>\n            genes were the main plasmid-mediated resistance genes, with prevalences ranging between 19.5% and 45% according to the ESBL results. Molecular typing did not identify wide clonal diffusion. Plasmid analysis suggested the diffusion of low numbers of ESBL-encoding plasmids, especially in\n            <jats:named-content content-type=\"genus-species\">K. pneumoniae<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">E. cloacae<\/jats:named-content>\n            . However, the ESBL-encoding genes were observed in different plasmid replicons according to the bacterial species. The prevalences of ESBL subtypes differ according to the\n            <jats:named-content content-type=\"genus-species\">Enterobacteriaceae<\/jats:named-content>\n            species. Plasmid spread is a key determinant of this epidemiology, and the link observed between the ESBL-encoding plasmids and the bacterial host explains the differences observed in the\n            <jats:named-content content-type=\"genus-species\">Enterobacteriaceae<\/jats:named-content>\n            species.\n          <\/jats:p>","DOI":"10.1128\/aac.01911-16","type":"journal-article","created":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T02:30:41Z","timestamp":1481596241000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":60,"title":["Inventory of Extended-Spectrum-\u03b2-Lactamase-Producing Enterobacteriaceae in France as Assessed by a Multicenter Study"],"prefix":"10.1128","volume":"61","author":[{"given":"F.","family":"Robin","sequence":"first","affiliation":[{"name":"CHU Clermont-Ferrand, Laboratoire de Bact\u00e9riologie &amp; CNR de la R\u00e9sistance aux Antibiotiques, Clermont-Ferrand, France"},{"name":"UMR INSERM 1071 usc INRA2018, Universit\u00e9 d'Auvergne, Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Beyrouthy","sequence":"additional","affiliation":[{"name":"CHU Clermont-Ferrand, Laboratoire de Bact\u00e9riologie &amp; CNR de la R\u00e9sistance aux Antibiotiques, Clermont-Ferrand, France"},{"name":"UMR INSERM 1071 usc INRA2018, Universit\u00e9 d'Auvergne, Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bonacorsi","sequence":"additional","affiliation":[{"name":"UMR INSERM 1137, IAME, Univ Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"AP-HP, H\u00f4pital Rober-Debr\u00e9, CNR Escherichia coli, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Aissa","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie, CHRU de Nancy, Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Bret","sequence":"additional","affiliation":[{"name":"Department of Microbiology, La Source Hospital, CHR Orl\u00e9ans, Orl\u00e9ans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Brieu","sequence":"additional","affiliation":[{"name":"CH du Pays d'Aix, Laboratoire de Diagnostic Biologique des Maladies Infectieuses et d'Hygi\u00e8ne, Aix-en-Provence, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Cattoir","sequence":"additional","affiliation":[{"name":"CHU de Caen, Service de Microbiologie, Universit\u00e9 de Caen Basse-Normandie, EA4655 (\u00e9quipe Antibior\u00e9sistance), Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Chapuis","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, University Hospital of Dijon, BP 37013, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Chardon","sequence":"additional","affiliation":[{"name":"CH du Pays d'Aix, Laboratoire de Diagnostic Biologique des Maladies Infectieuses et d'Hygi\u00e8ne, Aix-en-Provence, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Degand","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie, Centre Hospitalier Universitaire de Nice, H\u00f4pital Archet II, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Doucet-Populaire","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie-Hygi\u00e8ne, Hopital Antoine B\u00e9cl\u00e8re, APHP, Universit\u00e9 Paris Sud, Clamart, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Dubois","sequence":"additional","affiliation":[{"name":"UMR 5234 CNRS, University Bordeaux 2, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Fortineau","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie-Virologie, H\u00f4pital de Bic\u00eatre, Assistance Publique\/H\u00f4pitaux de Paris, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Grillon","sequence":"additional","affiliation":[{"name":"Plateau technique de microbiologie, Laboratoire de bact\u00e9riologie, CHU Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Lanotte","sequence":"additional","affiliation":[{"name":"CHU de Tours, Laboratoire de Bact\u00e9riologie, Tours, France; Universit\u00e9 Fran\u00e7ois Rabelais, E5 Bact\u00e9ries et risque materno-f\u0153tal, UMR 1282 ISP, INRA, Nouzilly, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Leyssene","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie m\u00e9dicale, Centre hospitalier de la C\u00f4te Basque, Bayonne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Patry","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie, Centre Hospitalier Universitaire de Besan\u00e7on, Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Podglajen","sequence":"additional","affiliation":[{"name":"Microbiology, AP-HP, H\u00f4pital Europ\u00e9en Georges Pompidou, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Recule","sequence":"additional","affiliation":[{"name":"Bacteriology Department, CHU Grenoble, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ros","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie-Virologie-Hygi\u00e8ne, CHU de Saint-Etienne, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Colomb-Cotinat","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Institut de Veille Sanitaire, French Institute for Public Health Surveillance, Saint-Maurice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Ponties","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Institut de Veille Sanitaire, French Institute for Public Health Surveillance, Saint-Maurice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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