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The change from two aromatic rings in this head group to a single ring does not appear to detrimentally affect the antimalarial activity of the compounds. Data from\n            <jats:italic>in vitro<\/jats:italic>\n            heme binding and\n            <jats:italic>\u03b2<\/jats:italic>\n            -hematin inhibition assays suggest that the single aromatic RCQ compounds retain activities against\n            <jats:named-content content-type=\"genus-species\">Plasmodium falciparum<\/jats:named-content>\n            similar to those of CQ, although other mechanisms of action may be relevant to their activities.\n          <\/jats:p>","DOI":"10.1128\/aac.01913-16","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T01:55:24Z","timestamp":1487037324000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Simplified Reversed Chloroquines To Overcome Malaria Resistance to Quinoline-Based Drugs"],"prefix":"10.1128","volume":"61","author":[{"given":"Bornface","family":"Gunsaru","sequence":"first","affiliation":[{"name":"Department of Chemistry, Portland State University, Portland, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Burgess","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Portland State University, Portland, Oregon, USA"},{"name":"DesignMedix, Inc., Portland, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Westin","family":"Morrill","sequence":"additional","affiliation":[{"name":"DesignMedix, Inc., Portland, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane X.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Portland State University, Portland, Oregon, USA"},{"name":"DesignMedix, Inc., Portland, Oregon, USA"},{"name":"Portland Veterans Affairs Medical Center, Portland, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawheen","family":"Shomloo","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Portland State University, Portland, Oregon, USA"},{"name":"DesignMedix, Inc., Portland, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Smilkstein","sequence":"additional","affiliation":[{"name":"Portland Veterans Affairs Medical Center, Portland, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Liebman","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Portland State University, Portland, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Peyton","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Portland State University, Portland, Oregon, USA"},{"name":"DesignMedix, Inc., Portland, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/biot.200500038"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm7012375"},{"key":"e_1_3_2_4_2","volume-title":"World malaria report","year":"2015","unstructured":". 2015. 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