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Invasive\n                      <jats:italic toggle=\"yes\">Fusarium<\/jats:italic>\n                      infections are often destructive due to their prevalence in critically ill patients. Furthermore, severe superficial infections, like keratitis or endophthalmitis with potential loss of vision, are rising in incidence globally. Infections are difficult to treat due to the intrinsic resistance of\n                      <jats:italic toggle=\"yes\">Fusarium<\/jats:italic>\n                      against echinocandins and often high minimal inhibitory concentrations (MICs) for azoles. In this article, we assessed the\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      activity of the novel antifungals olorofim, manogepix, rezafungin, and ibrexafungerp, as well as the established but nonstandard drugs, natamycin and terbinafine, against a large set of molecularly identified clinical\n                      <jats:italic toggle=\"yes\">Fusarium<\/jats:italic>\n                      isolates via EUCAST microdilution. The tested isolates represent the clinically most relevant species of the\n                      <jats:italic toggle=\"yes\">F. solani<\/jats:italic>\n                      (FSSC),\n                      <jats:italic toggle=\"yes\">F. oxysporum<\/jats:italic>\n                      (FOSC),\n                      <jats:italic toggle=\"yes\">F. fujikuroi<\/jats:italic>\n                      (FFSC),\n                      <jats:italic toggle=\"yes\">F. incarnatum-equiseti<\/jats:italic>\n                      (FIESC),\n                      <jats:italic toggle=\"yes\">F. dimerum<\/jats:italic>\n                      (FDSC), and\n                      <jats:italic toggle=\"yes\">F. redolens<\/jats:italic>\n                      (FRSC) species complexes. While rezafungin and ibrexafungerp showed no effect on the\n                      <jats:italic toggle=\"yes\">Fusarium<\/jats:italic>\n                      spp. tested, a general antifungal susceptibility of\n                      <jats:italic toggle=\"yes\">Fusarium<\/jats:italic>\n                      against natamycin and manogepix was found. Specific profiles were detailed for terbinafine and olorofim. While species from the FDSC, FSSC, and FIESC show high MICs for olorofim, specific susceptibility rates were found for species of the FFSC and FOSC. Furthermore, we report specific susceptibilities for terbinafine against FDSC, FFSC, and FOSC species. These findings of complex- and species-specific olorofim and terbinafine\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      susceptibilities highlight the need for diagnostics below genus level.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.01913-24","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T09:00:22Z","timestamp":1747299622000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["<i>In vitro<\/i>\n                    activity of novel antifungals, natamycin, and terbinafine against\n                    <i>Fusarium<\/i>"],"prefix":"10.1128","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3435-6637","authenticated-orcid":true,"given":"Enrico","family":"Garbe","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/055s37c97","id-type":"ROR","asserted-by":"publisher"}],"name":"(Epi-)Genetic Regulation of Fungal Virulence, Leibniz Institute for Natural Product Research and Infection Biology-Hans Kn\u00f6ll Institute","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahsan","family":"Ullah","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/055s37c97","id-type":"ROR","asserted-by":"publisher"}],"name":"(Epi-)Genetic Regulation of Fungal Virulence, Leibniz Institute for Natural Product Research and Infection Biology-Hans Kn\u00f6ll Institute","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7246-5518","authenticated-orcid":true,"given":"Alexander Maximilian","family":"Aldejohann","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00fbnyb24","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Hygiene and Microbiology, University of W\u00fcrzburg","place":["W\u00fcrzburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Kurzai","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00fbnyb24","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Hygiene and Microbiology, University of W\u00fcrzburg","place":["W\u00fcrzburg, Germany"]},{"id":[{"id":"https:\/\/ror.org\/055s37c97","id-type":"ROR","asserted-by":"publisher"}],"name":"National Reference Center for Invasive Fungal Infections (NRZMyk), Leibniz Institute for Natural Product Research and Infection Biology-Hans Kn\u00f6ll Institute","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7361-495X","authenticated-orcid":true,"given":"Slavica","family":"Janevska","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/055s37c97","id-type":"ROR","asserted-by":"publisher"}],"name":"(Epi-)Genetic Regulation of Fungal Virulence, Leibniz Institute for Natural Product Research and Infection Biology-Hans Kn\u00f6ll Institute","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grit","family":"Walther","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/055s37c97","id-type":"ROR","asserted-by":"publisher"}],"name":"National Reference Center for Invasive Fungal Infections (NRZMyk), Leibniz Institute for Natural Product Research and Infection Biology-Hans Kn\u00f6ll Institute","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1364-3703.2011.00783.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-016-9993-7"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30448-5"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0013-2020"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00159-22"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005464"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn022"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12281-015-0225-2"},{"key":"e_1_3_3_10_2","unstructured":"World Health Organization. 2022. 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