{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:29:20Z","timestamp":1791980960924,"version":"4.4.0"},"reference-count":14,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"New York State American College of Clinical Pharmacy","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2025,6,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Infectious Diseases Society of America guidelines recommend 14 days of treatment for\n                      <jats:italic toggle=\"yes\">Candida spp<\/jats:italic>\n                      . urinary tract infections (UTIs). To our knowledge, no data are available to compare &lt;14 days for\n                      <jats:italic toggle=\"yes\">Candida spp<\/jats:italic>\n                      . UTI. This was a single-center, retrospective cohort study between 01 January 2015 and 01 January 2024. Hospitalized adults with\n                      <jats:underline>&gt;<\/jats:underline>\n                      1 urine culture with\n                      <jats:italic toggle=\"yes\">Candida spp<\/jats:italic>\n                      . and symptoms who initiated &gt;1 antifungal dose within 96 hours were included. Multiple exclusion criteria existed, including but not limited to if\n                      <jats:italic toggle=\"yes\">Candida spp<\/jats:italic>\n                      . were isolated from another site, antifungals were received for another indication, or the participant was asymptomatic. The primary outcome was clinical treatment success. Binary logistic regression was performed to further assess the relationship between fluconazole duration and clinical treatment success. Among 2,400 patients with candiduria, 45 and 58 in the 14-day and &lt;14-day cohorts were assessed after exclusion criteria were applied, respectively. Median (interquartile range) fluconazole duration was 14 (14\u201314) days in the 14-day cohort and 7 (5\u20137) in the &lt;14-day cohort. There was no difference in clinical treatment success in patients treated for 14 days vs &lt;14 days (14 days: 93.3% (42\/45) vs &lt;14 days: 93.1% (54\/58),\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 1.000; between-group difference (95% CI: 0.02 [\u22129.6 to 10]). Fluconazole duration did not have a significant association with clinical treatment success on binary logistic regression (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.503; odds ratio 0.917 [95% CI: 0.712\u20131.181]). There was no statistically significant difference in clinical treatment success in patients treated with fluconazole for a median of 14 days vs a median of 7 days for symptomatic\n                      <jats:italic toggle=\"yes\">Candida spp<\/jats:italic>\n                      . UTI. These data support the potential utility of shorter antifungal durations for\n                      <jats:italic toggle=\"yes\">Candida spp<\/jats:italic>\n                      . UTI.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.01920-24","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T09:00:12Z","timestamp":1745312412000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of shorter versus longer antifungal treatment durations for\n                    <i>Candida spp<\/i>\n                    . urinary tract infections among hospitalized adults"],"prefix":"10.1128","volume":"69","author":[{"given":"Jacob C.","family":"Govel","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/008rmbt77","id-type":"ROR","asserted-by":"publisher"}],"name":"State University of New York at Binghamton School of Pharmacy and Pharmaceutical Sciences","place":["Binghamton, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Seabury","sequence":"additional","affiliation":[{"name":"State University of New York Upstate University Hospital","place":["Syracuse, USA"]},{"id":[{"id":"https:\/\/ror.org\/040kfrw16","id-type":"ROR","asserted-by":"publisher"}],"name":"State University of New York Upstate Medical University","place":["Syracuse, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Asiago-Reddy","sequence":"additional","affiliation":[{"name":"State University of New York Upstate University Hospital","place":["Syracuse, USA"]},{"id":[{"id":"https:\/\/ror.org\/040kfrw16","id-type":"ROR","asserted-by":"publisher"}],"name":"State University of New York Upstate Medical University","place":["Syracuse, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramiro L.","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"State University of New York Upstate University Hospital","place":["Syracuse, USA"]},{"id":[{"id":"https:\/\/ror.org\/040kfrw16","id-type":"ROR","asserted-by":"publisher"}],"name":"State University of New York Upstate Medical University","place":["Syracuse, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie A.","family":"Parsels","sequence":"additional","affiliation":[{"name":"State University of New York Upstate University Hospital","place":["Syracuse, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7703-096X","authenticated-orcid":true,"given":"Wesley D.","family":"Kufel","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/008rmbt77","id-type":"ROR","asserted-by":"publisher"}],"name":"State University of New York at Binghamton School of Pharmacy and Pharmaceutical Sciences","place":["Binghamton, USA"]},{"name":"State University of New York Upstate University Hospital","place":["Syracuse, USA"]},{"id":[{"id":"https:\/\/ror.org\/040kfrw16","id-type":"ROR","asserted-by":"publisher"}],"name":"State University of New York Upstate Medical University","place":["Syracuse, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2013.09.004"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir109"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/313583"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00076-09"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-1807-y"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ933"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/313580"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101750"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad009"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofab434"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.9899"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac706"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa394"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01464-17"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.01920-24","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.01920-24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T09:01:10Z","timestamp":1749027670000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.01920-24"}},"subtitle":[],"editor":[{"given":"Pranita D.","family":"Tamma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,6,4]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6,4]]}},"alternative-id":["10.1128\/aac.01920-24"],"URL":"https:\/\/doi.org\/10.1128\/aac.01920-24","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,4]]},"assertion":[{"value":"2024-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication 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