{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:17:56Z","timestamp":1790522276859,"version":"4.1.0"},"reference-count":73,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T00:00:00Z","timestamp":1585008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["SAF2014-54336-R"],"award-info":[{"award-number":["SAF2014-54336-R"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["SAF2017-86192-R"],"award-info":[{"award-number":["SAF2017-86192-R"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,3,24]]},"abstract":"<jats:p>\n            Amphotericin B (AmB) is the antifungal with the strongest fungicidal activity, but its use has several limitations, mainly associated with its toxicity. Although some lipidic and liposomal formulations that present reduced toxicity are available, their price limits their application in developing countries. Flucytosine (5FC) has shown synergistic effect with AmB for treatment of some fungal infections, such as cryptococcosis, but again, its price is a limitation for its use in many regions. In the present work, we aimed to identify new drugs that have a minor effect on\n            <jats:named-content content-type=\"genus-species\">Cryptococcus neoformans<\/jats:named-content>\n            , reducing its growth in the presence of subinhibitory concentrations of AmB.\n          <\/jats:p>","DOI":"10.1128\/aac.01921-19","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T09:47:12Z","timestamp":1579772832000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":49,"title":["Identification of Off-Patent Drugs That Show Synergism with Amphotericin B or That Present Antifungal Action against Cryptococcus neoformans and\n            <i>Candida<\/i>\n            spp"],"prefix":"10.1128","volume":"64","author":[{"given":"Su\u00e9len Andreia","family":"Rossi","sequence":"first","affiliation":[{"name":"Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haroldo Cesar","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain"},{"name":"Universidade Estadual Paulista (UNESP), Faculdade de Ci\u00eancias Farmac\u00eauticas, C\u00e2mpus Araraquara, Departamento de An\u00e1lises Cl\u00ednicas, Araraquara, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Agreda-Mellon","sequence":"additional","affiliation":[{"name":"Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Lucio","sequence":"additional","affiliation":[{"name":"Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jos\u00e9 Soares","family":"Mendes-Giannini","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista (UNESP), Faculdade de Ci\u00eancias Farmac\u00eauticas, C\u00e2mpus Araraquara, Departamento de An\u00e1lises Cl\u00ednicas, Araraquara, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas Pablo","family":"Garc\u00eda-Cambero","sequence":"additional","affiliation":[{"name":"Toxicology Area, National Centre for Environmental Health, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Zaragoza","sequence":"additional","affiliation":[{"name":"Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31819efac0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12380"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku506"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.128.3320.361"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.84.6.1152-1160.1962"},{"key":"e_1_3_3_7_2","first-page":"377","article-title":"Aqueous pores created in thin lipid membranes by the polyene antibiotics nystatin and amphotericin B","volume":"2","author":"Finkelstein A","year":"1973","unstructured":"Finkelstein A, Holz R. 1973. Aqueous pores created in thin lipid membranes by the polyene antibiotics nystatin and amphotericin B. Membranes 2:377\u2013408.","journal-title":"Membranes"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117280109"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja075739o"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03570-14"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2011.01.015"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/154.1.76"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.13.6.914"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.12.021"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2012.00286"},{"key":"e_1_3_3_16_2","volume-title":"Cryptococcus. From human pathogen to model yeast","author":"Heitman J","year":"2011","unstructured":"Heitman J, Kozel TR, Kwon-Chung KJ, Perferct JR, Casadevall A. 2011. Cryptococcus. From human pathogen to model yeast. ASM Press, Washington, DC."},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/649858"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt221"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2014.12.001"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00647-15"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00188-18"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00263-19"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17147-x"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2016.1196301"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12941-015-0090-4"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00680-13"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00537-17"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00120-17"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00314-12"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01084-18"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00083"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt449"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1787\/9789264203709-en"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myy054"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-2836(03)00662-4"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(02)00669-4"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/bf00433108"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.34.1.1"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/bf00422114"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00007-10"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198916050-00001"},{"key":"e_1_3_3_42_2","first-page":"106","article-title":"Bile acids as drugs: principles, mechanisms of action and formulations","volume":"27","author":"Hofmann AF","year":"1995","unstructured":"Hofmann AF. 1995. Bile acids as drugs: principles, mechanisms of action and formulations. Ital J Gastroenterol 27:106\u2013113.","journal-title":"Ital J Gastroenterol"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197309272891303"},{"key":"e_1_3_3_44_2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/164_2019_226","volume-title":"Bile acids and their receptors. Handbook of experimental pharmacology","author":"Fiorucci S","year":"2019","unstructured":"Fiorucci S, Distrutti E. 2019. Chenodeoxycholic acid: an update on its therapeutic applications, p 265\u2013282. In Fiorucci S, Distrutti E (ed), Bile acids and their receptors. Handbook of experimental pharmacology, vol 256. Springer, New York, NY."},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21183"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2006.08.019"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145706007218"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00815"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00212-12"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myv109"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.08.028"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.4761"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.48.4.1335-1343.2004"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150859"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19542"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.42.s1.2.x"},{"key":"e_1_3_3_57_2","first-page":"621","article-title":"In vitro antifungal spectrum of ciclopiroxolamine","volume":"37","author":"Goudard M","year":"1989","unstructured":"Goudard M, Regli P, Lubrano N. 1989. In vitro antifungal spectrum of ciclopiroxolamine. Pathol Biol (Paris) 37:621\u2013623.","journal-title":"Pathol Biol (Paris)"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198529040-00002"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00004"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4439(93)90021-r"},{"key":"e_1_3_3_61_2","first-page":"125","article-title":"Anti-Candida activity of the anti-cancer drug tamoxifen","volume":"80","author":"Beggs WH","year":"1993","unstructured":"Beggs WH. 1993. Anti-Candida activity of the anti-cancer drug tamoxifen. Res Commun Chem Pathol Pharmacol 80:125\u2013128.","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.03165.x"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.06.040"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01564-08"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.4.6.1079-1087.2005"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00535"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2016.03.002"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2007.01.009"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2011.545349"},{"key":"e_1_3_3_70_2","first-page":"177","article-title":"Chronic cryptococcal meningitis: a new experimental model in rabbits","volume":"101","author":"Perfect JR","year":"1980","unstructured":"Perfect JR, Lang SD, Durack DT. 1980. Chronic cryptococcal meningitis: a new experimental model in rabbits. Am J Pathol 101:177\u2013194.","journal-title":"Am J Pathol"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1007\/bf00328721"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2016.01.017"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg301"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.8.1914"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01921-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01921-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:32:43Z","timestamp":1645486363000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01921-19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,24]]},"references-count":73,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,3,24]]}},"alternative-id":["10.1128\/AAC.01921-19"],"URL":"https:\/\/doi.org\/10.1128\/aac.01921-19","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,24]]},"assertion":[{"value":"2019-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01921-19"}}