{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:26:35Z","timestamp":1791897995117,"version":"4.3.4"},"reference-count":55,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Jiangsu Specially Appointed Professor of China"},{"name":"Jiangsu Medical Specialist Program of China"},{"name":"National Science Foundation of the Jiangsu Higher Education Institutions of China","award":["18KJA310002"],"award-info":[{"award-number":["18KJA310002"]}]},{"name":"Jiangsu Province \"Innovative and Entrepreneurial Team\" Program of China"},{"name":"National Key Research and Development Programs of China","award":["2018YFC0311003"],"award-info":[{"award-number":["2018YFC0311003"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2021,2,17]]},"abstract":"<jats:p>\n                    <jats:named-content content-type=\"genus-species\">Helicobacter pylori<\/jats:named-content>\n                    is a major global pathogen and has been implicated in gastritis, peptic ulcer, and gastric carcinoma. The efficacy of the extensive therapy of\n                    <jats:named-content content-type=\"genus-species\">H. pylori<\/jats:named-content>\n                    infection with antibiotics is compromised by the development of drug resistance and toxicity toward human gut microbiota, which urgently demands novel and selective antibacterial strategies.\n                  <\/jats:p>","DOI":"10.1128\/aac.01921-20","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T07:47:27Z","timestamp":1607932047000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["Dihydrotanshinone I Is Effective against Drug-Resistant Helicobacter pylori\n                    <i>In Vitro<\/i>\n                    and\n                    <i>In Vivo<\/i>"],"prefix":"10.1128","volume":"65","author":[{"given":"Peipei","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Helicobacter pylori Research Center, Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Helicobacter pylori Research Center, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Research Center for the Prevention and Treatment of Drug Resistant Microbial Infection, Youjiang Medical University for Nationalities, Baise, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Hang","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Helicobacter pylori Research Center, Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Helicobacter pylori Research Center, Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Helicobacter pylori Research Center, Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Helicobacter pylori Research Center, Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Helicobacter pylori Research Center, Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0085-6602","authenticated-orcid":true,"given":"Hongkai","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Helicobacter pylori Research Center, Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.04.022"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.09.004"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/9781555818005.ch3"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00333.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1909666"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708423"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.563"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13497"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12299"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05165.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00001-18"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2007.01.004"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2017.193"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/0091270005282630"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867327666200521124850"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2018.1474170"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.20077"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms131013621"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2015.07.008"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-019-00789-2"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.09.025"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104254"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104307"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.63.2236"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23030623"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.05.006"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9100658"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00004-19"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/1757913917743881"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-090816-093813"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/np060482d"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep16478"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx623"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2010.03.026"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-014-0261-3"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/914791"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073301"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.06213.x"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00418"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.07.011"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2015.08.009"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26828-0"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.02.017"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-001-1223-4"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-50520-6_2"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.03147.x"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi951852s"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/41483"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01176-06"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01973-18"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf055"},{"key":"e_1_3_3_53_2","article-title":"Pharmacopoeia of the People's Republic of China","author":"China Pharmacopoeia Commission","year":"2015","unstructured":"China Pharmacopoeia Commission. 2015. Pharmacopoeia of the People's Republic of China. Part 1. Chinese Medicines and Technology Press, Beijing, China.","journal-title":"Part 1. Chinese Medicines and Technology Press, Beijing, China"},{"key":"e_1_3_3_54_2","unstructured":"The United States Pharmacopieial Convention. 2016. The United States Pharmacopeia (USP39-NF34)."},{"key":"e_1_3_3_55_2","unstructured":"European Pharmacopoeia Committee. 2016. European Pharmacopoeia 9th ed."},{"key":"e_1_3_3_56_2","article-title":"Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically","author":"Clinical and Laboratory Standards Institute","year":"2018","unstructured":"Clinical and Laboratory Standards Institute. 2018. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard, 11th ed. CLSI document M07-A7. Clinical and Laboratory Standards Institute, Wayne, PA.","journal-title":"Approved standard, 11th ed. CLSI document M07-A7"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01921-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01921-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T16:51:08Z","timestamp":1645462268000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01921-20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,17]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,2,17]]}},"alternative-id":["10.1128\/AAC.01921-20"],"URL":"https:\/\/doi.org\/10.1128\/aac.01921-20","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,17]]},"assertion":[{"value":"2020-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01921-20"}}