{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:02:53Z","timestamp":1787166173405,"version":"build-2736575974"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The promotion of colonization with vancomycin-resistant enterococci (VRE) is one potential side effect during treatment of\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Clostridium difficile<\/jats:named-content>\n                    -associated diarrhea (CDAD), resulting from disturbances in gut microbiota. Cadazolid (CDZ) is an investigational antibiotic with potent\n                    <jats:italic>in vitro<\/jats:italic>\n                    activity against\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">C. difficile<\/jats:named-content>\n                    and against VRE and is currently in clinical development for the treatment of CDAD. We report that CDZ treatment did not lead to intestinal VRE overgrowth in mice.\n                  <\/jats:p>","DOI":"10.1128\/aac.01923-15","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T22:34:05Z","timestamp":1445898845000},"page":"628-631","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["Cadazolid Does Not Promote Intestinal Colonization of Vancomycin-Resistant Enterococci in Mice"],"prefix":"10.1128","volume":"60","author":[{"given":"Peter","family":"Seiler","sequence":"first","affiliation":[{"name":"Actelion Pharmaceuticals Ltd., Allschwil, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Enderlin-Paput","sequence":"additional","affiliation":[{"name":"Actelion Pharmaceuticals Ltd., Allschwil, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Pfaff","sequence":"additional","affiliation":[{"name":"Actelion Pharmaceuticals Ltd., Allschwil, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Weiss","sequence":"additional","affiliation":[{"name":"Actelion Pharmaceuticals Ltd., Allschwil, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ritz","sequence":"additional","affiliation":[{"name":"Actelion Pharmaceuticals Ltd., Allschwil, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Clozel","sequence":"additional","affiliation":[{"name":"Actelion Pharmaceuticals Ltd., Allschwil, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans H.","family":"Locher","sequence":"additional","affiliation":[{"name":"Actelion Pharmaceuticals Ltd., Allschwil, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00090-08"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181e6ab12"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.7416\/ai.2013.1948"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.08.026"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.4065\/81.4.529"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.19.2223"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2009.02.007"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01840.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2008.10.010"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01830-13"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.09.002"},{"key":"e_1_3_3_13_2","volume-title":"Cadazolid, a novel quinolonyl-oxazolidinone antibiotic with potent activity against Clostridium difficile: in vitro antibacterial activity and propensity for resistance development","author":"Locher HH","year":"2012","unstructured":"Locher HH, Pfaff P, Schroeder S, Specklin JL, Hubschwerlen C, Keck W. 2012. Cadazolid, a novel quinolonyl-oxazolidinone antibiotic with potent activity against Clostridium difficile: in vitro antibacterial activity and propensity for resistance development. Abstr 52nd Intersci Conf Antimicrob Agents Chemother, San Francisco, CA. http:\/\/www.icaac.org\/."},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2013.02.003"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt411"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00504-15"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43918"},{"key":"e_1_3_3_18_2","volume-title":"Abstr 54th Intersci Conf Antimicrob Agents Chemother","author":"Deshpande A","year":"2014","unstructured":"Deshpande A, Hurless KN, Cadnum JL, Chesnel L, Chan L, Kundrapu S, Donskey CJ. 2014. Effect of surotomycin, a novel lipopeptide antibiotic, on disruption of the microbiome and susceptibitility to colonization with enteric pathogens, abstr F-235. Abstr 54th Intersci Conf Antimicrob Agents Chemother."},{"key":"e_1_3_3_19_2","volume-title":"Abstr 53rd Intersci Conf Antimicrob Agents Chemother","author":"Hurless K","year":"2013","unstructured":"Hurless K, Cadnum JL, Chesnel L, Polinkovsky A, Deshpande A, Donskey CJ. 2013. Effect of surotomycin, a novel cyclic lipopeptide antibiotic, on intestinal colonization with vancomycin-resistant enterococci and Klebsiella pneumoniae in mice, abstr F-628. Abstr 53rd Intersci Conf Antimicrob Agents Chemother."},{"key":"e_1_3_3_20_2","volume-title":"Abstr 51st Intersci Conf Antimicrob Agents Chemother","author":"Jump RL","year":"2011","unstructured":"Jump RL, Nerandzic MM, Pultz MJ, Donskey CJ. 2011. Effect of antibiotics used for treatment of Clostridium difficile infection in intestinal colonization with vancomycin-resistant Enterococci and KIebsiella pneumoniae in mice, abstr B-1190. Abstr 51st Intersci Conf Antimicrob Agents Chemother."},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis440"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1086\/592710"},{"key":"e_1_3_3_23_2","volume-title":"Abstr 51st Intersci Conf Antimicrob Agents Chemother","author":"Nerandzic MM","year":"2011","unstructured":"Nerandzic MM, Donskey CJ. 2011. Emergence of fidaxomicin-resistant vancomycin-resistant enterococci in mice treated with fidaxomicin, abstr K-1476. 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