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The next-generation polymyxin SPR206 shows potent activity against multidrug-resistant Gram-negative pathogens with low toxicity. SPR206 exhibited higher activity against colistin-susceptible and colistin-resistant strains (MIC\n              <jats:sub>50<\/jats:sub>\n              \/MIC\n              <jats:sub>90<\/jats:sub>\n              = 0.12\/0.25 mg\/L), and resistance was only detected in 1\/118 strains (MIC \u22654 mg\/L). Mutations in\n              <jats:italic toggle=\"yes\">pmrCAB<\/jats:italic>\n              , linked to colistin resistance, do not seem to confer resistance to the novel polymyxin, which retains a high level of activity.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/aac.01940-24","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T13:06:09Z","timestamp":1747746369000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["The novel polymyxin analogue SPR206 exhibits higher activity than colistin against both colistin-susceptible and colistin-resistant strains of\n            <i>Acinetobacter baumannii<\/i>"],"prefix":"10.1128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6737-0239","authenticated-orcid":false,"given":"Michelle","family":"Outeda-Garc\u00eda","sequence":"first","affiliation":[{"name":"Microbiology Service and Institute for Biomedical 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Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Rodr\u00edguez-Coello","sequence":"additional","affiliation":[{"name":"Microbiology Service and Institute for Biomedical Research A Coru\u00f1a (INIBIC), Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC)","place":["A Coru\u00f1a, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Alejandra","family":"B\u00e1ez-Barroso","sequence":"additional","affiliation":[{"name":"Microbiology Service and Institute for Biomedical Research A Coru\u00f1a (INIBIC), Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC)","place":["A Coru\u00f1a, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Maceiras","sequence":"additional","affiliation":[{"name":"Microbiology Service and Institute for Biomedical Research A Coru\u00f1a (INIBIC), Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC)","place":["A Coru\u00f1a, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Alonso-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Microbiology Service and Institute for Biomedical Research A Coru\u00f1a (INIBIC), Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC)","place":["A Coru\u00f1a, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4248-503X","authenticated-orcid":true,"given":"Jorge","family":"Arca-Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Microbiology Service and Institute for Biomedical Research A Coru\u00f1a (INIBIC), Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC)","place":["A Coru\u00f1a, Spain"]},{"name":"CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto Salud Carlos III","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4949-0779","authenticated-orcid":true,"given":"Juan 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